Effectiveness of Lawsonia Inermis for psychopharmacological activity on staircase in Nmri mice

Objective: To evaluate the psychopharmacological activity of methanolic extract of Lawsonia inermis [Meli] in Albino mice

Study Design: Observational study

Place and Duration of Study: This study was conducted at the Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi from January, 2014 to June, 2014

Materials and Methods: The study was approved by the ethical review committee of the institute. Lawsonia inermis leaves were gathered from the botanical greenery enclosure of the Hamdard University premises their pharmacognostic details were authenticated from Eastern Medication Faculty of Hamdard University, Karachi. Albino mice [30-35g] of either sex were gotten from the creature place of Dr. HMI Institute of Pharmacy and Herbal Sciences, Hamdard University, Karachi. Psychopharmacological activity was studied by utilizing stair case test which is normally utilized as a part of rat for hostile to tension like conduct that is based comprises of setting local queasiness in an encased box with 5 steps. Absolutely thirty six [N=36] were arbitrarily partitioned into six sets. For each of the model considered [n=6]. The groups incorporate controls [vehicle] and standard medications [Diazepam, Buspirone, 1mg/kg] and three groups of Meli [50, 100 and 200 mg/kg]

Results: Meli dosage of 100mg/kg drastically [P<0.05, 0.01] augmented the number of steps up in the Stair case with peak activity procured at the dosage of 100mg/kg [37.8 +/- 4.2] seconds compared to control [6.3 +/- 2.2 Seconds]. The extract at dosage of 100mg/kg notably [P<0.05, 0.01] accelerated the number of steps up with peak effect at the dosage of 100mg/kg [37.8 +/- 4.2] compared to control [6.3 +/- 2.2 seconds]. The impact at this measurement was not quite different that of Diazepam [41.8 +/- 3.4 seconds]

Conclusion: Meli has explored anxiolytic effect because it possesses one or a mix of Phytoconstituents in the concentrate

Effect of drugs; baehavior of mice measured by modified hole board head-dipping exploratory test parameter

The aim of this study was to determine head-dipping exploratory test parameter as a measure of strong modulating effect on brain and behavior. It was an observational animal study. University of Karachi. Period: Jan 2004 to July 2006. In this present study, drugs used reserpine, nux- vomica; anacardium and chlorpromazine were wide range of pharmacological actions. We evaluate the effectiveness of these drugs as agents with modulating effect on brain and behavior accessed by head dipping parameter. In this study, 25 mice were included belonging to both sexes. The study animals were divided into five groups of five animals each. Four groups were given drugs and one group was kept as control. Mice [20-35g] of either sex were used in this study. One group was kept as control for drugs. Mice were kept under room temperature. Tap-water was allowed ad-Lihitum.30 minutes after giving drugs, animals were observed for 10 minutes with two minutes of interval. Tablet crushed in 10ml of water, 1 cc was given. Screening method used was head dipping. Strychnos Nux-Vomica when used in a dose of 0.07mg has strong action on cholinergic system, CNS activity and frequent head dipping [39.8 +/- 28.8] was observed. Rauwolfia serpentine is an active alkaloid particularly present in reserpine [62.2 +/- 43.4] no significant head dipping effect was observed. Anacardium [37.2 +/- 28.6] and Chlorpromazine [39.4 +/- 32.4], show decrease effects. Keeping in view, the medicinal importance of these herbs, our present study was designed to screen these drugs for CNS activity on albino mice

Psychopharmacological activity; evaluation of the effectiveness of nux-vomica, reserpine, anagardium and chlorpromazine herbal medicines

The purpose of this study was to screen some herbal medicine as psychotropic drugs those has strong modulating effect on brain and behavior. Herbal drug Reserpine, Nux- Vomica, Anacardium and Chlorpromazine with a wide range of pharmacological actions. In our present study, we evaluate the effectiveness of these drugs as Psychotropic agents and accessed by biochemical-parameters. Rats [weighing 180-250g] and Mice [22-32g] either sex were used in this study. One group was kept as control for drugs. Mice were kept under room temperature. Tap-water was allowed ad-Libitum. Animals were observed during and after 21 days. A tablet crushed in 10ml of water, 1cc was given. Screening method used was swimming induced-despair. Among these, Strychnos Nux-Vomica has strong action on cholinergic system, CMS activity and observed as an antispasmodic. Rauwolfia serpentine is an active alkaloid particularly present in reserpine are used to treat essential hypertension and in certain neuropsychiatry disorders. It has sedative and tranquilizing effects, as it depletes catecholamine from the central nervous system. Keeping in view, the medicinal importance of these herbs, our present study was designed to screen these herbs as for CMS activity on Albino mice and rats

Screening of some herbal medicines for psychopharmacological activity

In our present study, we evaluate the effectiveness of these drugs as Psychotropic agents and accessed by biochemical-parameters. Experimental and Observational Study. This Study was conducted at the Faculty of Pharmacy, Hanidard University, Karachi from Jan 2009 to June 2009. Study on Mice [Part-A]: Rats [weighing 180-250g] and Mice [22-32g] either sex were used in this study. One group was kept as control for both drugs. Mice were kept under room temperature. Part B The effect of herbal medicine and homeopathic drugs are investigated on psychotrophic parameters of rats. Doses were given according to the body weight of rats. Screening of herbal medicine as psychotropic drugs has strong modulating effect on brain and behavior. Majority of Pakistani population lives in far-flung rural area where modern medicines are not easily available, so they rely on traditional herbal medicines for relief. This signifies the importance of Eastern system of medicine in our society and stresses the need of research on herbal medicines like. Some of the herbal drug Reserpine, Nux-Vomica, Anacardium and Chiorpromazine with a wide range of pharmacological actions. Among these, Strychnos Nux-Vomica has strong action on cholinergic system, CNS activity and observed as a antispasmodic. Rauwolfia serpentine is an active alkaloid particularly present in reserpine are used to treat essential hypertension and in certain neuropsychiatry disorders. It has a sedative and tranquilizing effects, as it depletes catecholamine from the central nervous system. Keeping in view, the medicinal importance of these herbs, our present study was designed to screen these herbs as for CNS activity on Albino mice and rats