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Indian J Physiol Pharmacol ; 1980 Oct-Dec; 24(4): 351-6
Artigo em Inglês | IMSEAR | ID: sea-107518

RESUMO

Injection of heparin as well as antigenic challenge in sensitized guinea pigs are known to produce a release of histaminase into the plasma. In the present study, tissue histaminase estimation was done by Spencer's method (17) and plasma estimation by Kapellar Adler's (7) method. Mepyramine pretreatment considerably decreased the histaminase release by both heparin and anaphylaxis. Mepyramine did not antagonise the anticoagulant action of heparin in vitro.


Assuntos
Amina Oxidase (contendo Cobre)/metabolismo , Aminopiridinas/farmacologia , Anafilaxia/enzimologia , Animais , Feminino , Cobaias , Heparina/farmacologia , Fígado/enzimologia , Masculino , Pirilamina/farmacologia
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