RESUMO
Background: Studies of oxidative status in polycystic ovarian syndrome [PCOS] patients are limited with inconsistent results. The effects of resveratrol as a natural antioxidant on oxidative status in PCOS aren't clear
Objective: This study evaluated effects of resveratrol on oxidative stress in the liver and serum of the PCOS rats
Materials and Methods: Fifteen female Wistar rats [3 wk old] were divided into 3 groups [n=5/each e]: Control group, PCO-Control group, and PCO-Resveratrol group. For induction of polycystic ovary phenotype, testosterone enanthate 10 mg/kg was injected for 35 days subcutaneously. Then, resveratrol 10 mg/kg was injected intraperitoneally for 28 days to rats of the PCO-Resveratrol group. Ovarian sections were stained with hematoxylin/eosin. The serum glucose and insulin and the levels of malondialdehyde [MDA] and total antioxidant capacity [TAC] in serum and liver were measured
Results: Control animals showed normal ovarian morphology and PCO-Control animals exhibited cystic follicles. There were no significant differences in liver TAC between groups. The serum MDA [p=0.034], and homeostatic model assessment insulin resistance [HOMA-IR] [p=0.014] levels in PCO-Control rats were higher than the controls. The liver MDA in PCO-Control rats was more than that of controls [p=0.001]. The HOMA-IR [p=0.008] and serum MDA [p=0.006] levels in PCO-Control rats were more than those of PCO-Resveratrol rats [p=0.008]. In PCO-Resveratrol group, serum TAC was higher than that of PCO-Control group [p=0.022] and liver MDA was more than controls [p=0.01]
Conclusion: Results indicated that the induction of PCOS in rats increased lipid peroxidation and insulin resistance and resveratrol improved these complications