RESUMO
Eighty subjects were selected for this study, 65 of them were patients of liver cirrhosis [43 males and 22 females] and 15 of them were normal individuals as a control group [11 males and 4 females]. All the 80 subjects were subjected to full clinical assessment, biochemical liver profile, kidney profile, abdominal ultrasonography and estimation of plasma prostaglandin E2 [PGE2]. It was found that PGE2 was significantly increased in cirrhotic patients and this increase was more in ascitic than non-ascitic patients and more in Child C patients than in other Child classes, but there is evident marked significant drop in PGE2 level with the development of hepatorenal syndrome [HRS]. It was concluded that the increase of the vasodilator PGE2 in cirrhotic patients is a protective factor against the catastrophic effect of increased vasoconstrictor mediators characteristic of liver cirrhosis and the drop of PGE2 could be a causative factor in pathogenesis of HRS as it drops leaving the kidney under the vigorous effect of vasoconstrictors. The study postulated a new formula which might be more sensitive for the prediction of HRS
Assuntos
Humanos , Masculino , Feminino , Síndrome Hepatorrenal , Testes de Função Hepática , Prostaglandinas E , Testes de Função RenalRESUMO
This study was carried in the Surgical Department of Kasr El-Aini University Hospital over a period extending from November 1995 through December 1998. Twenty patients suffering from chronic duodenal ulccration, 14 males and 6 females, with a mean age of 38.8 years, who presented for surgery, were included in the study. The indications for surgery constituted failure of long term medical treatment [12 cases], complications [4 cases], frequent relapses [2 cases]. Pre-operative endoscopic biopsy from the gastric antrum revealed positive H.pylori infestations in all cases. 3 months following trunkaI vagotomy and gastroentcrostomy, re-endoscopy revealed healing of the ulcers in all cases. Biopsies obtained from within one inch of the gasto-enterostomy revealed however, persistence of H. pylori in 40% [8] of cases
Assuntos
Humanos , Masculino , Feminino , Doença Crônica , Endoscopia/métodos , Infecções por Helicobacter , Vagotomia Troncular , Gastroenterostomia , Helicobacter pylori , Resultado do TratamentoRESUMO
Several new pyrazolopyridines VIa-c were synthesized by reacting 4-nitrosoantipyrine [IIa] with arylidenemalononitriles Ia-c or ethyl arylidenecyanoacetates If-h. Reaction of Ia-c with 4-[azidomethylcarbonyl] antipyrine [IIb] afforded the pyridine derivatives XVI. The 4H-pyrans and naphthodipyran derivatives XVIII- XXI were prepared by reacting I with polyhydric phenols
Assuntos
Pirazóis/análogos & derivados , Piranos/análogos & derivados , Compostos Heterocíclicos/síntese química , Piridinas/síntese química , Pirazóis/síntese química , Piridinas/síntese químicaRESUMO
Thirty patients undergoing endoscopic retrograde cholangiopancreatography [ERCP] were studied. Blood samples were taken just before, 5 minutes after cannulation of the papilla and, 15 minutes after the end of examination. The samples were cultured for both aerobic and anaerobic organisms. Seven cases [23.3%] showed positive cultures. The isolated organisms in 4 of them were considered as normal commensals of the skin. While in 3 cases [10%], the organism, were considered pathogenic. We concluded that ercp is a safe procedure and not accompanied by bacteraemia except in the immunocompromised cases. Thus, the immunocompromised patients should be considered a high risk for the development of bacteraemia following ERCP. The use of prophylactic antibiotics is recommended before and after procedure in all immunodepressed patients and patients with chronic valvular diseases