Relationship between Enterobius Vermicularis infection and pelvic inflammatory diseases in children at Sohag Governorate, Egypt

A cohort of children presented with pelvic inflammatory diseases [gastro-intestinal and/or genitourinary surgical conditions] and had concomitant infection with E. vermicularis. To find out this relationship, a total of 135 patients suffering from different gastro-intestinal and genitourinary surgical conditions were selected from Departments of Surgery and Gynecology. They were subjected to stool analysis, peri-anal swabs and blood examination mainly for eosinophilia. The results showed that 26 patients out of 135 [19.2%] had. E. vermicularis with high eosinophilia in 30 cases [22.2%]. Identification of E. vermicularis by peri-anal swab test in the cohort was successful [16.30%]. Males were more affected than females with ratio 2.2:1 and age mean 7.13 +/- 1.92. As to residence and housing, rural children with bad housing [73.08% and 88.46% respectively] were more affected than those living in urban areas with healthy housing [26.92% and 11.54% respectively]

Comparative study between the effect of nitazoxanide and paromomycine in treatment of cryptosporidiosis in hospitalized children

Ninety children infected with Cryptosporidium parvum attending Al Azhar University Teaching Hospital [Assuit] were chosen [60 males and 30 females] with age range from 6 months to ten years. The patients were divided into two groups of 45 patients for each [G1 and G2]. All patients suffered from chronic diarrhea for more than fifteen days. Cross-matched 45 children suffering from chronic diarrhea were used as a control group [G3]. Stool samples were collected and examined for detection of Cryptosporidium oocysts using Sheather's sugar and Modified Ziehl-Nelseen stain techniques. The first group [G1] received Nitazoxanide [100 mg and 200 mg every 12 hours for 3 days for children aged 6 months to 3 years, and children aged 4 to 10 years respectively], G2 received Parornomycin [25mg/kg/day for 2 weeks]. Third group received placebo. Significant improvement and shortening of the duration of diarrhea occur in G1; of 45 patients received Nitazoxanide 39 cases showed complete clinical and laboratory cure [86.6%], 5 cases showed clinical improvement with reduction in the number of oocysts and 1 case showed no cure. In G2 of 45 cases received Paromomycin 31 cases showed complete cure [68.8%], 8 cases showed clinical improvement with reduction of oocysts number and 6 cases were not cured. Nitazoxanide proved highly effective than Paromomycin in cryptosporidiosis