RESUMO
Herbal remedies are used in induction of lactation. In view of that .Borage Officinalis was employed to ensure an abundant milk supply or rectify milk insufficiency .However, this remedy has not been scientifically tested .The animals were treated with the aqueous extract of Borage Officinalis flowers at a daily concentration of 100 mg / kg body weight /ml for each rat through Oro-gastric tube for 14 days. Animals were subdivided into subgroups according to their physiological status. Mammary glands of these animals were processed for histological, histochemical and immunohistochemical studies. Parameters indicated that the aqueous extract of Borage Officinalis flowers induced lactogenesis in the mammmary glands of virgin and pregnant rats and promoted lactation when had given to lactating rats. Borage Officinalis is a lactogenic herb
RESUMO
A detailed cytogenetic investigation was carried out on two sensitive and resistant cell lines, the human chronic myelogenous Ieukemia [k562] and the human burkitt lymphoma [DAUDI]. These cell lines have shown numerous clonal karyotypic alterations. However, numerical alteration was the more common [most notably chromosome gain]. The resistant sublines-R have shown chromosomal rearrangement unique to the resistant sublines. The k562-R subline was characterized by the presence of homogenous staining region [HSR] located at the long arm of chromosome no. 7 while the DAUD1-R was characterized by the presence of double minute chromosomes [DMs]