Chromosomes studies in 100 couples with repeated fetal wastage

Cytogenetic studies performed for 100 couples with a history of two or more early or late pregnancy loss revealed that in 8 couples [8%], one partner was a carrier of a chromosome anomaly. These included four cases of triple X females and four cases of structural aberrations. In addition, the presence of minor polymorphic variants was demonstrated in seven couples. Analysis of the frequencies of chromosome aberrations according to number of fetal wastages, type of fetal wastage and consanguinity revealed comparable results. However, a higher consanguinity rate was observed among couples with mixed reproductive wastage [67%] as compared to couples with only first trimester abortions [42%]