chemiluminescent response of macrophages in mice infected with schistosoma mansoni

Peritoneal phagocytic cells when stimulated by Schistosoma mansoni infection in this study, exhibited a sudden increase in oxygen consumption known as a respiratory burst. This resulted in the production of toxic oxygen metabolites [H[2] O[2] and others]. The level of the toxic oxygen metabolites [chemiluminescence/cells] in normal mice and in mice infected with S. mansoni was measured in vitro. One week, one and two months after infection, a highly significant increase in the levels of chemiluminescence/cell was observed when compared to that of the normal control group. These oxygen metabolites have long been known to have microbicidal activity, and may take part in the ecytotoxic role in cell-mediated immune response against all stages of schistosomal life cycle in this study

Schistosoma mansoni: production of tumour necrosis factor [TNF] in experimentally infected mice

TNF has been proposed as one of the macrophage derived cytotoxins, so the present work aimed at studying the influence of the different stages of Schistosoma mansoni life cycle on the active secretion of TNF by stimulated macrophages in mice. The results revealed that infection with S. mansoni induced a high significant increase in the TNF production at one week, one and two months of infection compared to normal controls. TNF production of one month infected group was significantly reduced in comparison with the one-week infected group. Two months after infection with S. mansoni insignificant increase in the TNF production was observed, coin-pared to that of the one-week infected group, and significantly increased with respect to the group of one-month post-infectior