RESUMO
Objective: To compare the effect of intravitreal triamcinolone [IVT] alone with combined intravitreal triamcinolone [IVT] and intravitreal bevacizumab [IVB] on central macular thickness [CMT] in patients of diabetic macular edema [DME]
Study Design: Randomized control trial
Place and Duration of Study: Armed Forces Institute of Ophthalmology, Jun 2013 to Dec 2013
Material and Methods: Eighty patients were included in the study through non probability consecutive sampling and were randomized to IVT alone or IVT + IVB group using random number table. Pre and post injection [12 weeks] CMT were recorded and intra and inter group comparison was performed
Results: Both groups showed statistically significant reduction in mean CMT at 12 weeks [p<0.05]. In Group A, mean CMT reduction at 12 weeks was 64.33 microns [SD=15.17] while in Group B it was 75.18 [SD=20.82]. On comparison, IVT + IVB group was more effective in reducing CMT with statistically significant difference [p=0.009]
Conclusion: Intravitreal triamcinolone used in combination with IVB is more effective in reducing central macular thickness in diabetic macular edema [DME] than intravitreal triamcinolone alone
RESUMO
Objective: To compare the mean retinal nerve fiber layer [RNFL] thickness in Primary open angle glaucoma [POAG] patients and healthy age matched adults
Study Design: Case control study
Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi from 12[th] December 2011 to 17[th] October 2012
Material and Methods: Sixty subjects were included in the study, 30 cases and 30 controls, by non-probability consecutive sampling. In group A, patients of POAG were included and in group B, healthy adults having normal intraocular pressure were included. Mean retinal nerve fiber layer thickness [RNFL] measurements and mean of three intraocular pressure [IOP] readings of 30 patients of POAG were taken. RNFL thickness was obtained by spectral domain optical coherence tomography. IOP readings were taken with calibrated Goldman applanation tonometer
Results: Mean RNFL thickness of 66.19 +/- 14.83 microns in group A eyes was significantly lower than mean RNFL thickness of 96.46 +/- 14.76 microns in normal adults [p<0.001]
Conclusion: The overall thinner mean retinal nerve fiber layer thickness in POAG patients as compared with normal age matched individuals highlights the importance of early diagnosis and prompt intervention in such patients to reduce the morbidity related to potentially blinding but treatable disease like glaucoma