RESUMO
Objective: to create acute pancreatitis condition experimentally in rats using cerulein, and to reveal histopathological effects in pancreatic tissue with erdosteine
Study Design: an experimental study
Place and Duration of Study: department of General Surgery, Duzce University, Turkey, from June to October 2014
Methodology: thirty male Wistar albino rats were divided into three groups. No procedures were applied to Group 1. The rats in Group 2 and Group 3 were injected cerulein, to establish an experimental pancreatitis model and the blood amylase and lipase values were examined. The rats in Group 3 were given 10 mg/kg erdosteine. This treatment was continued for another 2 days and the rats were sacrificed. The pancreatic tissues were examined histopathologically for edema, inflammation, acinar necrosis, fat necrosis, and vacuolization
Results: the lipase and amylase values and the histopathological examination of pancreatic tissues evidenced that the experimental acute pancreatitis model was established and edema, inflammation, acinar necrosis, fat necrosis, and vacuolization were observed in the pancreatic tissues. The statistical results suggest that erdosteine can decrease the edema, inflammation, acinar necrosis, fat necrosis and vacuolization scores in the tissues
Conclusion: the severity of acute pancreatitis, induced by cerulein in rats, is reduced with the use of erdosteine
RESUMO
Cardiac rhythm problems are frequently seen in the geriatric population, and they can experience trauma after syncope. A 78-year-old female was examined for thoracic trauma after falling. With a history of -blocker use, arterial blood pressure measured 60/30 mmHg and pulse rate was 30 bpm. Electrocardiogram showed a Mobitz type-II second-degree atrioventricular block. There was no response to atropine, so a transcutaneous external pacemaker and after that a transvenous pacemaker were applied. On the 4th day, the pacemaker was removed and the patient was discharged