RESUMO
The frequency and severity of human infections associated with Corynebacterium ulcerans appear to be increasing in different countries. Here, we describe the first C. ulcerans strain producing a diphtheria-like toxin isolated from an elderly woman with a fatal pulmonary infection and a history of leg skin ulcers in the Rio de Janeiro metropolitan area.
Assuntos
Idoso de 80 Anos ou mais , Feminino , Humanos , Broncopneumonia/microbiologia , Infecções por Corynebacterium/microbiologia , Corynebacterium/metabolismo , Toxoide Diftérico/biossíntese , Úlcera da Perna/microbiologia , Brasil/epidemiologia , Broncopneumonia/diagnóstico , Infecções por Corynebacterium/diagnóstico , Infecções por Corynebacterium/epidemiologia , Corynebacterium/isolamento & purificação , Evolução Fatal , Úlcera da Perna/diagnósticoRESUMO
Mycobacterium simiae is usually an environmental contaminant rarely associated with human disease. We report a fatal case of M.simiae infection in a 37 year old, HIV positive, male from whom the organism was isolated from blood culture. The identification of M.simiae was performed using DNA amplification followed by analysis on 3 agarose gel of the amplicon fragments after digestion by restriction endonucleases. The precise identification of mycobacterial isolates to the species level is important, with both epidemiological and therapeutic implications.