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1.
Southeast Asian J Trop Med Public Health ; 1990 Mar; 21(1): 69-75
Artigo em Inglês | IMSEAR | ID: sea-34136

RESUMO

Sixty-four out of 189 jaundiced patients at San Lazaro Hospital were defined as acute viral hepatitis cases. Of this number, 22 (34.4%) were positive for hepatitis A markers while 26 (40.6%) were positive for hepatitis B markers. Hepatitis D infection accounted for 1.6%, while non-A, non-B hepatitis accounted for 21.9%.


Assuntos
Doença Aguda , Adolescente , Adulto , Idoso , Feminino , Hepatite A/diagnóstico , Anticorpos Anti-Hepatite/análise , Hepatite B/diagnóstico , Antígenos de Superfície da Hepatite B/análise , Vírus da Hepatite B/isolamento & purificação , Hepatite C/diagnóstico , Hepatite D/diagnóstico , Vírus Delta da Hepatite/isolamento & purificação , Hepatite Viral Humana/diagnóstico , Hepatovirus/isolamento & purificação , Humanos , Técnicas Imunológicas , Icterícia/microbiologia , Masculino , Pessoa de Meia-Idade , Filipinas
2.
Southeast Asian J Trop Med Public Health ; 1987 Jun; 18(2): 179-82
Artigo em Inglês | IMSEAR | ID: sea-36247

RESUMO

The dose response of Plasmodium falciparum isolates in the standard in vitro assay for drug resistance was compared using blood specimens which were centrifuged and washed before cultivation. Washing of the cultures increased the success of cultivation by greater than 100%. Eight cultures which grew using both methods gave similar results in the determination of resistance or sensitivity. The ED50 as determined by probit analysis, was approximately 50% higher in parasites which had been washed before cultivation.


Assuntos
Animais , Cloroquina/farmacologia , Resistência a Medicamentos , Humanos , Mefloquina , Parasitologia/métodos , Plasmodium falciparum/efeitos dos fármacos , Quinolinas/farmacologia , Manejo de Espécimes
3.
Southeast Asian J Trop Med Public Health ; 1987 Jun; 18(2): 202-6
Artigo em Inglês | IMSEAR | ID: sea-33011

RESUMO

A long term study was carried out at San Lazaro Hospital, Manila, Philippines, monitoring the in vitro response of Plasmodium falciparum to chloroquine, amodiaquine, mefloquine, and quinine. The in vitro effective dose giving 50% inhibition of schizogony was: 0.68 X 10(-6) M/liter blood for chloroquine; 0.18 X 10(-6) for amodiaquine; 0.2 X 10(-6) for mefloquine; and 1.12 X 10(-6) for quinine. The percent of isolates determined to be resistant in vitro was 85.2% for chloroquine, and 1.2% for both mefloquine and quinine. These figures were relatively unchanged over the course of 3 years studied. The in vitro resistance rate to amodiaquine increased from 5.1% in 1982 to 22.2% in 1984.


Assuntos
Amodiaquina/farmacologia , Animais , Antimaláricos/farmacologia , Cloroquina/farmacologia , Resistência a Medicamentos , Humanos , Malária/parasitologia , Mefloquina , Filipinas , Plasmodium falciparum/efeitos dos fármacos , Quinina/farmacologia , Quinolinas/farmacologia
4.
Southeast Asian J Trop Med Public Health ; 1985 Dec; 16(4): 534-8
Artigo em Inglês | IMSEAR | ID: sea-32715

RESUMO

Forty-six patients with Plasmodium vivax malaria were evaluated for their clinical and parasitological response to the two single doses of mefloquine in comparison with the standard 3-day treatment with chloroquine. The patients were randomly distributed into 3 groups. Group 1 with 13 patients were treated with a single dose 250 mg mefloquine, Group 2 with 15 patients were treated with a single dose 500 mg mefloquine and Group 3 with 18 cases were treated with the standard 3-day treatment course of 1,500 mg chloroquine. All patients in the three treatment group showed similar parasite, clearance time, fever clearance time and clearance time of signs and symptoms. There were no statistically significant differences between any of the groups. The age and weight, as well as the initial parasite count of the three groups were comparable. This study shows that mefloquine at the dosages used were as effective as the 3-day standard treatment with 1,500 mg chloroquine.


Assuntos
Adolescente , Adulto , Antimaláricos/uso terapêutico , Cloroquina/uso terapêutico , Feminino , Humanos , Malária/tratamento farmacológico , Masculino , Mefloquina , Pessoa de Meia-Idade , Plasmodium vivax , Quinolinas/uso terapêutico
5.
Southeast Asian J Trop Med Public Health ; 1984 Jun; 15(2): 161-6
Artigo em Inglês | IMSEAR | ID: sea-34768

RESUMO

Eight hundred blood cultures were tested in parallel in three conventional systems: tryptic soy broth containing 0.05% sodium polyanethosulfonate (TSB-SPS), whole blood in bile (BILE-BLOOD), and blood clots in bile (BILE-CLOT). Sixty-eight cultures were Salmonella typhi positive and 29 were positive for S. paratyphi A in at least one of the systems. Analysis of the isolation rates of the 97 Salmonella-positive specimens showed that BILE-BLOOD was significantly more sensitive (p less than 0.05) than either TSB-SPS or BILE-CLOTS, and that the latter two were not significantly different. The time required for positive results was shortest in BLOOD-BILE which was significantly quicker than BILE-CLOTs (p less than 0.05), but not TSB-SPS (p greater than 0.05). Possible explanations for the observed, superior performance of the BILE-BLOOD system are discussed and recommendations for efficient recovery of enteric fever salmonellae from blood are presented.


Assuntos
Bile , Sangue/microbiologia , Meios de Cultura , Humanos , Febre Paratifoide/diagnóstico , Polianetolsulfonato , Salmonella paratyphi A/isolamento & purificação , Salmonella typhi/isolamento & purificação , Febre Tifoide/diagnóstico
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