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J Indian Med Assoc ; 2022 Jan; 120(1): 43-45
Artigo | IMSEAR | ID: sea-216479

RESUMO

Gastrointestinal Stromal Tumours (GISTs) are one of the rare causes of Alimentary Tract Neoplasm. They arise from the Interstitial Cells of Cajal (ICC) with overexpression of proto-oncogenes like KIT, PDGFRA and BRAF-Kinase, etc1. The typical location of these tumors is the stomach with Jejunal GIST being the rarest variant. The maximal incidence of the disease is reported in the sixth decade of life. GISTs are often asymptomatic and clinicians are misdirected towards a different diagnosis because of its variable nature of presentation. The clinical feature typically ranges from non-specific abdominal symptoms like nausea, vomiting, bloating, etc, to abdominal emergencies like hemorrhage, anemia, or obstruction. Although mostly benign, there is a high probability of progression to malignancy2. Thus, in patients with no appreciable cause of gastrointestinal bleed or chronic abdominal discomfort, GIST should have high suspicion index. This can help to limit the progression and thereby prevent further complications. Due to its location, it is difficult to identify by Endoscopy or Colonoscopy. Single Balloon Enteroscopy (SBE) and CT Scan of Abdomen are the primary investigational modalities. The treatment aims at resection of the mass with continued Postsurgical surveillance and targeted molecular therapy in some cases. Herein, we report a 14-year-old boy with chronic paleness and gradual onset repeat episodes of Melaena. Despite repeated blood transfusions, the patient had a Hemoglobin

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