RESUMO
Metformin is a biguanide oral hypoglycemic drug used primarily in the treatment of DM. Nigella sativa (Activeingredient, Thymoquinone) has been found effective in lowering serum glucose levels and has protective effectspreventing the complications of Diabetes Mellitus. Diabetes Mellitus causes several complications, affectingalmost every organ of the body. The objective of this study was to investigate the effects of DM on liver, heartand kidney and to observe the protective as well as curative effects of Metformin and Nigella sativa from thosecomplications. The results obtained indicate that DM causes inflammation in liver and kidney and also leads tohydropic changes. While no significant changes could be observed in the heart during the study, it was observedthat Both Nigella sativa and Metformin decrease the early inflammatory changes caused by STZ induced DM inthe rat liver and kidneys but the hydropic changes continue.