Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trial

Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects.

Review on applications of electric ehicles in the countryside / Revisão de aplicações de veículos elétricos no meio rural

ABSTRACT: This paper presents the main applications of electric vehicles in rural areas, pointing out the trends and challenges for the future. Technological conditions and difficulties faced by the industry for a wide dissemination of this technology are discussed. The paper described the main researches with proposals to overcome the problems of implementing electric tractors, as supply and electricity storage. Technical and economic comparisons between conventional internal combustion tractors and electric tractors are also presented and discussed. The paper showed the existence of barriers to the implementation of electric vehicles in rural areas, as well as the need for batteries technological evolution, which have high costs and for that reason they are very heavy for these purposes, but there are already systems that can be applied to minimize dependence of fossil fuels in this sector and increase the use of sustainable energy.

RESUMO: Este artigo apresenta as principais aplicações de veículos elétricos no meio rural, apontanto as tendências e mudanças futuras. O trabalho discute também as condições tecnológicas e dificuldades enfrentadas pelo setor industrial para a inserção do veículo elétrico no mercado. São apresentados os principais pesquisadores da área com propostas para superar os problemas da implementação dos tratores elétricos, tais como abastecimento e armazenamento de energia elétrica. As comparações técnicas e econômicas entre tratores convencionais, a combustão interna, e tratores elétricos são apresentadas e discutidas. A revisão mostra a existência de barreiras para a implantação dos veículos elétricos no meio rural, como a necessidade de evolução tecnológica das baterias, que apresentam alto custo e ainda são pesadas para este propósito, mas mostra também que já existem sistemas que podem minimizar a dependência de compubstíveis fóceis do setor e aumentar o uso de energia sustentável.