Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages

Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 æg/ml and 50 æg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 æg/ml and 1250 æg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages

Quantificacao de imunocomplexos circulantes atraves do PEG a 3,5%.Caracterizacao no lupus eritematoso sistemico e outras nefropatias. / Quantification of circulating immunocomplexes through the PEG 3,5%.Characterization in lupus erythematosus systemic and other renal diseases

No presente trabalho, os autores introduzem um metodo rapido de quantificacao de imunecomplexos circulantes e analisam o seu comportamento no lupus eritematoso e comparam os dados obtidos com aqueles observados em outras nefropatias