RESUMO
Displasia fibrosa óssea é uma doença que pode comprometer um ou vários ossos do esqueleto. Ocorre com maior frequência nas três primeiras décadas de vida, sem predileção por sexo. Apresenta uma etiopatogenia controversa, desde distúrbios de desenvolvimento, problemas endócrinos a mutações genéticas. O diagnóstico é baseado em características clínicas, exames de imagem, exames laboratorial e histopatológico. O diagnóstico diferencial é feito principalmente com fibroma ossificante. Cirurgias reconstrutivas, curetagens,e medicamentos bifosfonados são à base do tratamento. Este artigo relata um caso de um paciente portador de hipotireoidismo congênito que apresenta displasia fibrosa óssea na mandíbula.
Fibrous dysplasia of bone is a disease which can involve only one or several bones of the skeleton. It occurs more frequently in the first three decades of life and has no sex predilection. It shows a controversy etiopathogeny ranging from development disorders, endocrine problems to gene mutations. The diagnosticis based on clinical features, imaging studies, lab tests, and anatomopathologic analyses. The differential diagnosis is made mainly using ossifying fibroma. The reconstructive surgeries, curettage, and bisphosphonate drugs are the basis of the treatment. This article reports a case of a patient who has congenital hypothyroidism that presents fibrous dysplasia of bone of the jaw.
Assuntos
Humanos , Masculino , Adulto , Difosfonatos/uso terapêutico , Displasia Fibrosa Monostótica/diagnóstico , Hipotireoidismo Congênito/complicaçõesRESUMO
By using improved pulsed field gel electrophoresis conditions, the molecular karyotype of the reference chromosomal bands ranging in size from 0.45 to 3.5 Magabase pairs (Mbp) were resolved in a single run. The weighted sum of the chromosomal bands was approximately 87 Mbp. Chromoblots were hybridized with 39 different homologous probes, 13 of which identified single chromosomes. Several markers linkage and four different linkage groups were identified, each comprising two markers. Densitometric analysis suggests that most of the chromosomal bands contain two or more chromosomes representing either homologous chromosomes and/or heterologous chromosomes with similar sizes.