RESUMO
Erythrina mulungu Mart. ex Benth., Fabaceae, popularly known as mulungu, is used for the treatment of insomnia and disorders of the central nervous system. This study examined the antinociceptive effects of the hydroalcoholic extracts (HAE), the ethyl acetate and chloroformic fractions from E. mulungu in four experimental models of nociception using laboratory mice. The extracts and fractions were administered orally to mice at doses of 100 mg/kg. Inhibition of abdominal contractions were observed for all the extracts and fractions tested, as compared to controls. All extracts and fractions from E. mulungu reduced the nociception activity produced by formalin in the 2nd phase. In the hot plate test no significant effect was observed for any extract or fraction. In the peritonitis test induced by Zymosan, all of the tested extracts and the chloroformic fraction, except for the ethyl acetate phase, reduced cell migration of the peritoneal cavity. We concluded that E. mulungu shows antinociceptive effects, which are independent of the opioid system.
RESUMO
O objetivo do estudo foi avaliar as intervenções para promoção de atividade física (AF) ofertadas pela prefeitura municipal de Curitiba, Paraná (PMC). Para tal, realizou-se um inquérito domiciliar com 120 adultos igualmente distribuídos entre os sexos, e residentes próximos a Centros de Esporte e Lazer (CEL) da cidade. A seleção dos CEL ocorreu de forma aleatória, e as residências foram abordadas de maneira sistemática. Entre os entrevistados, 76% já viram, 15% participaram/participam de algum programa, 48% realiza AF nos espaços disponibilizados pela PMC e 43% ouviu falar do Programa CuritibAtiva. Apenas 10% dos entrevistados relataram ter recebido algum folder do programa CuritibAtiva e uma proporção ainda menor (0,8%) disseram que participam/participaram das atividades promovidas pelo programa CuritibAtiva. Mais da metade dos usuários atribuiu boa/ótima avaliação aos itens dos programas. Desta forma os programas da PMC parecem ser abrangentes, bem difundidos e bem avaliados por seus usuários.
The aim of this study was to evaluate community physical activity (PA) programs offered by the Curitiba municipality administration. We carried out a household-based study including 120 adults (equally distributed by sex), living close to sports and leisure centers (CEL). CELs were randomly sampled, and households around each selected CEL were systematically approached. Out of the 120 interviewees, 76% saw, 15% participate/have participated of at least one of the programs offered by the municipality. Approximately half (48%) of the respondents practiced PA in the city public spaces, or heard about the CuritibAtiva program (43%). Only 10% and 0.8% of the subjects reported to have received a flyer or to participate/have participated of the CuritibAtiva program, respectively. More than half of the interviewees rated as good or excellent the items of the programs. We conclude that Curitiba programs seem to be widely known by the city population, as well as rated positively by the interviewees.