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Aims:TheaimthisresearchworkistoformulateandevaluatethermoreversiblegelofantifungalagentClotrimazolefortreatmentofvaginalinfection.PlaceandDurationofStudy:DepartmentofBiopharmaceutics,GovernmentCollegeofPharmacy,Karad,Maharashtra,India,betweenJune2009andJuly2010.Methodology:DifferentFormulationsofthermoreversiblegelofantifungalagentClotrimazolewerepreparedbyusingvariousconcentrationsofethanol,PEG400,sodiumdodecylsulphate,polycarbophilandpluronicF127andpluronicF68.Thegelformulationsweresubjectedforevaluationonthebasisofrheologicalbehaviour,mucoadhesivebehaviour,in-vitroperformance.Results:TheresultsindicatethatPolymerssuchaspolycarbophil,PEG-400invariousconcentrationstoprepareformulationswerefoundtoreleasedrugforperiodover12hrs.Withoutgettingdislodged.Theformulationshavesatisfactoryrheologicalbehaviorandtheirdiffusionprofileiscomparabletothemarketedgelformulation.Significantdifferencewasobservedintherheologicalbehaviorofformulations.Gelstrength,spreadability,mucoadhesivestrengthofformulationBandCweredesirable.DrugdiffusionofformulationBandCwere95.2%releaseafte 11hrs98.5%releaseafter11hrs,respectivelywhichwasgoodascomparedtomarketedformulationshowingdrugdiffusionof102.2%after10hrs.Conclusion:OnbasisoftheresultsweconcludedthatdevelopedthermoreversiblegelofClotrimazolewillbebetteralternativetoconventionaldosageformClotrimazole&willimprovepatientcompliance
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Background: Whole-grain consumption is associated with several health benefits. Little is known, however, about whole-grain consumption patterns in medical students in Malaysia. Objectives: The study was conducted to assess whole-grain intake pattern and factors influencing intake among Malaysian medical students. Methods: A cross-sectional study investigating whole-grain intake among 151 medical students in a private medical university in Malaysia was conducted from January to June 2018. A self-administered questionnaire was used to assess sociodemographic variables, the whole-grain intake pattern and the knowledge and attitudes toward whole-grain intake. Data were analyzed using IBM SPSS software. Chi-square test and multivariable logistic regression were used. Results: The prevalence of reported whole-grain intake in the past 3 months was 51%. Chinese ethnicity, readiness to adhere to Malaysian food pyramid, and self-preparation of food, and eating at home were significantly associated with whole-grain consumption. However, the primary determinants of food choice such as education, knowledge, and affordability did not seem to influence whole-grain consumption. Whole-grain consumption is relatively low among Malaysian medical students. Cultural background and self-belief influence this practice despite being from the medical fraternity. Conclusions: Efforts are needed to bridge the knowledge–practice gap by assessing the barriers to whole-grain consumption to design effective initiatives to promote an increase in whole-grain consumption.
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Amlapitta is one of the leading problems of new era due to irregular and improper diet, dietetics and stressful life style. It is a very common disorder of Annavahasrotasa caused by Vidagdha Pitta with features like, Abipaka (indigestion), Klama (fatigue), Utklesha (nausea), Tikta-Amlodgara (sour or bitter eructation), Gourava (heaviness), Hritkanthadaha (heart burn), Aruchi (anorexia) etc., Amlapitta include acid peptic disorders (APD)- gastroesophageal reflux disease (GERD), Peptic ulcer diseases (PUD), dyspepsia and functional disorder of GI tract, In the present study, aimed to compare the efficacy of Jeerakadya Ghrita Arohanakrama Snehapana (increasing order) followed by Virechana with Trivrit Churnaadi yoga and Patolashunti Ghrita Arohanakrama Snehapana followed by Virechana with Trivritchurnadi yoga in the management of Adhoga Amlapitta. Material and methods: A minimum of 30 patients suffering from Adhoga Amlapitta were selected in 2 groups, 15 patients in each group. Group A- 15 patients were given Jeerakadya Ghrita Arohanakramasnehapana and Virechana. Group B-15 patients were given Patolashunti Ghrita Arohanakramasnehapana and Virechana. Follow up for 14 days (Patients will be assessed clinically on day 0, 7th day & 14th day). Total study duration is 35days. Virechana is highly significant on all the parameters, except Bhrama at both the phases. Statistical analysis of Group A and Group B are showing same result, but there will be reduction percentage in sign and symptoms like Agnimagda, Trishna, Hrillasa, Bhrama, Vividhavarnayoukta Malapravritti Group A is given better result.
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Uterine arteriovenous malformation (AVM) is a rare condition, with fewer than 100 cases reported in the literature. Despite it being rare, it is a potentially life-threatening condition. This case report describes a healthy 29-year-old patient, nulligravida, with an unremarkable medical history, came from gynaecologist for ultrasaound due to complain of irregular heavy PV bleeding. Transvaginal Doppler ultrasonography is a widely available, noninvasive and excellent diagnostic method. Transvaginal ultrasound (TVS) of the pelvis showed increased vascularity with multidirectional flow of the uterus and a prominent vessel, located on the posterior wall.