RESUMO
Background: The association between diabetes mellitus [DM] and thyroid dysfunction is well known. However, the prevalence of having DM with thyroid dysfunction is extremely variable from one study to another. Clinical relevance of thyroid disorders in diabetic patients leads to serious consequences with metabolic compensation of diabetes
Objectives: to find the prevalence of thyroid dysfunction in T2D retrospectively through the data available in our diabetic centers among those who attended the diabetic clinics for routine checkup
Patients and Methods: This is a retrospective cohort study conducted from January to August 2017 at three diabetic centers in Makkah and Jeddah, Kingdom of Saudi Arabia. Nine hundred and seventy-nine patients aged between 30 and 65years, of both genders with T2D were randomly selected. The participants` data were collected from their files, using a data collection checklist prepared for the study
Results: The study included 979 T2D patients. The prevalence of thyroid dysfunction among T2D patients was 13.1%. Mean age amongT2D patients with thyroid dysfunction was 48.8 years whereas the mean age among T2D patients with hypertension was 58.5 years. Females were significantly more presented with T2D and thyroid dysfunction. Again, T2D associated with thyroid dysfunction and hypertension was significantly more in females than males. Duration of diabetes was significantly more among patients having T2D, thyroid dysfunction and hypertension than those with only T2D and thyroid dysfunction. Oral antidiabetics [OADs] were more frequently used than combination of OADs and insulin while diet and exercise only were less, however thyroid dysfunction was more among them. Majority of our participants with T2D and thyroid dysfunction reported the occurrence of T2D first
Conclusion: The prevalence of thyroid disorder is quite high amongT2D patients. Prevalence was higher in female patients and relatively younger ages. Early detection of thyroid dysfunction in patients with T2Dis of great importance and consequences
RESUMO
Background: Cirrhosis is the irreversible fibrosis of liver, it continues to be a common cause of morbidity and mortality. It is accompanied by inflammation and malnutrition and thus can have a negative effects on bone metabolism and promote fractures accordingly
Aim of the study: to evaluate the risk of fractures among patients with cirrhosis
Methods: A systematic review of the scientific literature following PRISMA/STROBE guidelines, Medline Cochrane Library and Embase s were retrieved using an algorithm comprising relevant MeSH terms from 1980 to 2017. Publications on the association of cirrhosis/bone fracture were ed independently by the authors and included in both gender and gender-specific meta-analyses, following recalculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies
Results: [st] 8 udies met the inclusion criteria enrolling 988 patients [286 of which are diagnosed with al coholic liver disease [ALD]. Overall, ALD demonstrated a el r ative risk [] RR of 1.825, 95%CI: 1.370 2.28, - < 0.001 P for the development of bone fractures. Bone mineral density [BMD] was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD. Sensitivity analyses showed consistent results
Conclusion: in accordance to the present meta-analysis, there is a significant correlation between bone fractures and ALD independent of BMD