RESUMO
Cancer is one of the leading causes of death worldwide. Present treatment options include chemotherapy, radiationtherapy, and surgery, all of which have side effects. In order to mitigate the side effects of these treatments, there isa need to look for combinational or alternative treatment, which is based on natural sources. Present study aims toscreen the whole plant extracts of Sesuvium portulcastrum for its antiproliferative activity against various cancer celllines. Different extracts of S. portulacastrum were prepared using ethanol, methanol, acetone, hexane, and diethylether as solvent. Their anticancer activity was evaluated against human breast cancer cells (MDA-MB-231), humanneuroblastoma cell line (IMR-32), and human colon cancer cells (HCT-116) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Propidium iodide staining method was used to observe the apoptosisassociated morphological changes under the microscope. Among the five extracts, diethyl ether extract showed thehighest activity with IC50 values of 288.69 ± 6.53 μg/ml for MDA-MB-231, 231.01 ± 6.31 μg/ml for IMR-32, and182.86 ± 4.29 μg/ml for HCT-116 cell lines. Our results suggest that the extracts of S. portulacastrum exhibit goodanticancer activity against the different cell lines tested.
RESUMO
Introduction: Coronary heart disease is the leading cause of death in Western countries and it is now an increasing problem in developing countries too, due to changes in life style and dietary habits. Heart Disease is responsible for more deaths and disability among Western Population, both male and female, than any other killer disease, and it is quickly establishing itself as the leading cause of death and disability among Indians as well. Aim of the Study: To study relation between risk factors for atherosclerosis and fasting and postprandial triglyceride levels in patients of Coronary artery disease. To establish that post-prandial triglycerides level is a better indicator as a ‘risk factor’ for atherosclerosis. Materials and methods: A complete physical and cardiovascular system examination performed. Blood pressure measurements were performed with mercury sphygmomanometer in a standardized fashion. Waist circumference was measured at umbilical level. Hip circumference was measured at maximum girth at hip. Recording of ECG was done with 12 leads recording in standard fashion with B.P.L machine. Fasting samples of blood glucose, Fasting Lipid profile was measured. Results: In our study, out of 56 male 34 (62.5%) were suffering from diabetes mellitus while 30 female out of 44 were (68.18%) diabetic. So out of 100 patients 64 patients were suffering from Murugan, Sathvika. Study of post-prandial hypertriglyceridemia as an independent risk factor for ischemic heart disease in Government Dharmapuri Medical College, Dharmapuri. IAIM, 2017; 4(7): 173-178. Page 174 diabetes. In our study, 57 patients were hypertensive. 32 male patients out of 56 male patients were hypertensive (57.14%) and 25 female patients out of 44 patients (56.81%) were hypertensive. In the present study, postprandial hypertriglyceridemia was found in 16 patients out of 23 patients (69.5%) in the age group 35-45, 31 patients out of 46 patients (67.39%) in the age group 46-55, 9 out of 21 patients (42.8%) in the age group 56,-65, and 8 patients out of 10 (80%) in the age > 66 years. Conclusion: In our study with reference to patient of ischemic heart disease, postprandial Hypertriglyceridemia was found in 64% patients, having normal fasting triglyceride level. There is statistically a significant correlation between postprandial triglyceride and ischemic heart disease, even in patients having normal fasting triglyceride level. It means that patients having high postprandial triglyceride levels have higher risk of Ischemic heart disease. The relative risk is 1.44.
RESUMO
Introduction: Mean platelet volume (MPV) and Platelet Distribution Width (PDW) is a relatively simple, inexpensive tool that indicates the platelets size, the rate of platelet production, platelet activation and the severity of inflammation since inflammation plays an important role in COPD, any alteration in platelet activity can cause alteration in MPV. Red blood cell distribution width (RDW) reflects morphology of erythrocytes whereas RDW can also vary due to systemic inflammation and ineffective erythropoiesis. Hence we aimed to study Platelet indices in patients with exacerbation of COPD. Aim and objectives: Our aim is to evaluate the role of platelet Indices in COPD patients. Since only limited data were available on the relationship between COPD and platelet indices, we aimed to evaluate and find out the correlation between Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW), Platelet Distribution Width (PDW) and Plateletcrit (PCT) in exacerbation of COPD patients at a tertiary care hospital in south India. Materials and methods: A total of 135 subjects, 79 men and 56 women, who were admitted in our hospital with exacerbation of COPD during a period of one year were enrolled in this prospective Ragulan R, Viswambhar V, Krishnaveni R, Meenakshi Narasimhan, Aruna Shanmuganathan, Nisha Ganga, Gangaiamaran M. Evaluation of platelet indices among patients with exacerbation of COPD in a tertiary care center in South India. IAIM, 2017; 4(7): 161-166. Page 162 observational study. The levels of MPW, RDW, PDW and PCT were assessed during the course of hospital stay in patients with COPD exacerbation Results: In our study we found out that there exists a statistical significance among male and female COPD exacerbation patients with respect to Mean Platelet Volume (P=<0.0001) and Red Cell Distribution Width (P=<0.0001). There also exists statistical significance between our COPD patients with other study stable controls (p=<0.005). Using ROC curve, considering optimal level of MPV <8.8Fl, male population showed sensitivity of 95% and specificity of 85% with Average age in men with diagnosed COPD is 49 and average age of female COPD patient is 55. Conclusion: Our study suggests that Mean Platelet Volume and Red Cell Distribution Width values may be useful for identifying patients who are at high risk for exacerbation of COPD. RDW per se is an important risk factor for Ischemic heart disease (IHD) and elevated RDW may suggest increase in risk of IHD in patients with COPD