Monoclonal gammopathy, a three year study on paraproteinemias

Sera from 22 patients [16 males + 6 females] with electrophoretically and immunologically secured diagnosis of monoclonal gammopathy were tested for various biochemical parameters. The final clinical diagnosis showing gamma-globulinemias in them was in the order of multiple myeloma [MM] 20 nos, Waldenstrom macroglobulinemia [MW] 1 no. and light chain disease [LCD] 1 no. The incidence of plasma cell neoplasm among Saudies is not very rare. The predominant type is IgG myeloma [74%] with a kappa to lambda ratio of 2: 1. Bence Jones Proteinuria is comparativly less common. Elevated levels of gamma glutamyl transpeptidase [GGT] in a good number of patients indicate the high occurrence of hepatic involvement in such patients