Comparative effect of tiaprofenic acid and piroxicam alone and as adjuvants to praziquantel in schistosoma mansoni infected mice

Non-steroidal anti-inflammatory drugs [NSAIDs] [tiaprofenic acid and piroxicam] have been used alone and as adjuvants to praziquantel in treating hepatic granuloma in Schistosoma mansoni infected mice. Granuloma diameter, histamine metabolism, cyclic AMP and PGE2 levels have been measured at the end of treatment. Tiaprofenic acid effectively reduced the size of hepatic granuloma, significantly increased histamine forming capacity, CAMP level and significantly decreased plasma PGE2 level. Piroxicam had no significant effect on granuloma size, significantly decreased histamine forming capacity, CAMP and PGE2 levels. The combined therapy of either of the drugs with praziquantel did not result in an additive effect

Effects of prolonged administration and abrupt withdrawal of nifedipine on some endocrine and metabolic parameters in normal rabbits

The effect of prolonged oral administration of nifedipine [four weeks] in three dose levels 1, 3 and 10 mg/kg/day] as well as the effect as measured on the third day following abrupt withdrawal of the drug on plasma levels of adenocorticotrophic hormone [ACTH] and serum levels of cortisoly triiodothyromine [T3] thyroxine [T4], insulin, glucose and free fatty acids [FFAs] was studied in normal rabbits. Nifedipine decreased plasma ACTH serum insulin and FFAs levels at the three doses used. A decrease of serum T[3] level occurred at the 1 mg/kg dose. Meanwhile it increased serum cortisol at 10 and 3 mg/kg doses and serum glucose at the 10 mg/kg dose. Withdrawal of nifedipine still showed an increase in serum cortisol at the 10 mg/kg dose as a result of persistence of its pharmacodynamie effect. Also it increased serum FFAs at the 10 and 3 mg/kg doses; while a decrease of serum T[3] was noted at the 10 and 3 mg/kg doses. A decrease of serum insulin at the three doses used occurred on the third day after abrupt cessation of the drug