Resistin serum levels and its association with clinical profile and carotid intima-media thickness in psoriasis: a cross-sectional study

Abstract Background Psoriasis is a protean disease associated with several comorbidities that may have increased levels of adiponectin such as resistin. This may affect the patients atherosclerotic risk. Objective To study resistin levels in a sample of Brazilian patients with psoriasis and its association with clinical profile, comorbidities, and carotid Intima-Media Thickness (cIMT). Methods This is a cross-sectional study of 119 individuals: 34 healthy controls and 85 patients with psoriasis, 42 of which with skin involvement only and 43 with psoriatic arthritis. Clinical and epidemiological data, measurement of PASI (Psoriasis Area Severity Index) and DAPSA (Disease Activity in Psoriatic Arthritis), lipid profile, cIMT by ultrasound were collected from medical records. Resistin serum levels were measured by ELISA. Results Patients with psoriasis had higher resistin levels (p = 0.009) and worse cIMT (p = 0.0002) than controls. In the psoriasis sample, no associations of resistin levels with epidemiological, clinical findings, and activity indexes were found. Resistin serum levels were associated with the presence of diabetes (p = 0.008) and metabolic syndrome (p = 0.01) and correlated with total cholesterol (r = 0.26) and triglycerides (r = 0.33) but not with cIMT. Study limitations This work is limited by its transversal design and by the limited number of patients included. Conclusion Resistin serum levels are elevated in psoriasis patients. In this sample, clinical, epidemiological, and activity indexes were not linked to resistin serum levels, but atherosclerotic risk factors were.

Saúde LGBTQIA+: análise na educação médica / LGBTQIA+ health: analysis in medical education

O trabalho insere-se nas áreas temáticas da atenção à saúde da população LGBTQIA+ e da formação dos profissionais de saúde focada nesta área. Tem por objetivo analisar o conhecimento específico dos estudantes de medicina do Paraná, Brasil, no atendimento à saúde da população LGBTQIA+ e realizar levantamento do nível de conhecimento referido pelos estudantes acerca da atenção à saúde da população LGBTQIA+. Foram entrevistados 240 acadêmicos de medicina de 11 instituições de ensino médico do Estado do Paraná, por intermédio de questionário eletrônico disponibilizado via redes sociais, e analisadas as porcentagens das respostas. A maior parte (68,4%) "discordam totalmente" ou "discordam" que receberam formação específica na área de atendimento à saúde da população LGBTQIA+. Há pouca familiaridade dos estudantes com a terminologia existente dentro desse universo. Em conclusão, percebe-se a necessidade de adequação da educação médica no que concerne às especificidades da saúde da população LGBTQIA+

The work is part of the thematic areas of health care for the LGBTQIA+ population and the training of health professionals focused on this area. It aims to analyze the specific knowledge of medical students in Paraná, Brazil, in the health care of the LGBTQIA+ population and to carry out a survey of the level of knowledge reported by the students about the health care of the LGBTQIA+ population. A total of 240 medical students from 11 medical education institutions in the State of Paraná were interviewed, using an electronic questionnaire made available via social networks, and the percentages of responses were analyzed. Most (68.4%) "strongly disagree" or "disagree" that they received specific training in the area of health care for the LGBTQIA+ population. There is little familiarity of students with the terminology existing within this universe. In conclusion, there is a need to adapt medical education with regard to the health specifics of the LGBTQIA+ population