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1.
Korean Journal of Obstetrics and Gynecology ; : 1869-1876, 1999.
Artigo em Coreano | WPRIM | ID: wpr-167356

RESUMO

Holoprosencephaly is a rare malformation complex or development defect including different degrees of incomplete cleavages of the embryonic prosencephalon and varying degrees of the midface defects, resulting from the defect of prechordal mesoderm, migrating forward into the area anterior to the notochord during the third week of fetal development. Early antenatal diagnosis of holoprosencephaly is important to find out its severity, to predict its prognosis, and to determine proper management according to its prognosis and severity. The possibility of early antenatal diagnosis of holoprosencephaly by ultrasound has been suggested, but occasionally missed and rarely confirmed. We present one case of lobar holoprosencephaly, diagnosed postnatally and one case of alobar holoprosencephaly, diagnosed antenatally in our hospitals.


Assuntos
Desenvolvimento Fetal , Holoprosencefalia , Mesoderma , Notocorda , Diagnóstico Pré-Natal , Prognóstico , Prosencéfalo , Ultrassonografia
2.
Korean Journal of Obstetrics and Gynecology ; : 2088-2093, 1999.
Artigo em Coreano | WPRIM | ID: wpr-213668

RESUMO

Cervical pregnancy is a rare and dangerous form of ectopic pregnancy in which the blastocyst implants within the cervical canal below the internal os of the uterine cervix. The characteristic clinical sign is a severe asymptomatic uterine bleeding in early pregnancy or during curettage. Most cervical pregnancies result in early spontaneous abortion, complicated by severe hemorrhage from the eroded blood vessels within the cervical tissue. Because of uncontrolled profuse vaginal bleeding, total hysterectomy has been the mostly necessitated to control life-threatening bleeding. Transvaginal sonography allows early diagnosis, and conservative treatment (two-time treatment : first treatement with systemic or intraamnionic methotrexate, secondly with curettage or ligature of the uterine arteries) improves the patient's fertility. Successful treatment is defined as elimination of the cervical pregnancy with preservation of the uterus. We report two cases of cervical pregnancy managed, successfully with methotrexate, leucovorin and curettage.


Assuntos
Feminino , Humanos , Gravidez , Aborto Espontâneo , Blastocisto , Vasos Sanguíneos , Colo do Útero , Curetagem , Citocromo P-450 CYP1A1 , Diagnóstico Precoce , Fertilidade , Hemorragia , Histerectomia , Leucovorina , Ligadura , Metotrexato , Gravidez Ectópica , Hemorragia Uterina , Útero
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