study on red cell enzymes in acute lymphoblastic leukaemia in attack and remission

This study comprised 40 children and included two groups; the first group consisted of 20 healthy children as control, their ages ranged from 2-12 years. The second group comprised 20 cases, their ages ranged from 18 month to 11 years. This group was classified into 11 cases in the acute attack; from them 7 cases were diagnosed as ALL of L2 category according to FAB classification and 4 of the L1 category. 9 cases came in remission, all were diagnosed as LL before

Antineutrophil cytoplasmic autoantibodies[ANCA] in active systemic lupus erythematosus

To test the presence of Antineutrophil cytoplasmic Autoantibodies [ANCA] in active SLE cases and its relationship to disease activity, 20 patients with active SLE [mean age=25 +/- 9.1 years] and 10 healthy controls [mean age=29 +/- 1.5 years] were studied. All were subjected to the following investigations: C.B.C, E.S.R, C.R.P., blood urea, serum creatinine, L.E, cell test, detection of DNA by agglutination method, cDNA and ANCA by indirect immunofluorescent technique. Four cases [20%] were found to have c-ANCA, one [5%] was found to have P-ANCA and 15 cases [75%] were negative to ANCA. A statistically significant decrease was found in ANCA-negative cases when compared with ANCA-positive cases as regard; renal function test, T.L.C., absolute neutrophil count, ESR and total score of the disease activity. It may be concluded that ANCA may have a significant value as a marker of SLE activity and may be of pathogenic significance in SLE cases