RESUMO
The aim of this study is synthesis of two different series of organoselenium compounds and available in vitro antioxidant and antimicrobial properties of these synthetic compounds. The synthetic compounds were identified by [1]HNMR [300 MHz], [13]C-NMR [75.5 MHz], FT-IR spectroscopic techniques and micro analysis. Antioxidant properties of two synthetic organoselenium compounds were determined by 1, 1- diphenyl-2-picrylhydrazyl [DPPH] radical method, reducing power assay and beta-carotene bleaching method as in vitro. Antimicrobial effects of samples were assessed by the agar dilution procedure and using gram positive and gram-negative bacteria and yeast strains. Although 1, 3-di-p-methoxybenzylpyrimidine- 2-selenone showed better antiradical activity in DPPH test and higher protective activity on beta- carotene, 1-isopropyl-3-methylbenzimidazole-2-selenone was found to be better in reducing power and antimicrobial activity
Assuntos
Antioxidantes , Anti-Infecciosos , Espectroscopia de Ressonância Magnética Nuclear de Carbono-13 , Espectroscopia de Prótons por Ressonância Magnética , Espectroscopia de Infravermelho com Transformada de Fourier , Compostos de Bifenilo , PicratosRESUMO
Background: Although the rate of multiple drug resistance is high, there is no published data on the transmission rate of drug-resistant strains of Mycobacterium tuberculosis in the Aegean region of western Turkey that are based on molecular methods
Methods: IS6110 and pTBN12 restriction fragment length polymorphism [RFLP] methods were used for typing M. tuberculosis strains isolated from 26 sputum samples from 26 patients
Results: Nineteen of the rifampin-resistant isolates [73.1%] contained 6 to 11 copies of IS6110. Eighteen different IS6110 DNA fingerprint patterns were observed in the 26 rifampin-resistant isolates. Twenty-three of the 26 rifampin-resistant isolates were also resistant to isoniazid. When evaluated together, both methods yielded 21 [80.9%] different banding patterns and the level of clustering was 34.6%. The average number per pattern was 1.23 [26/21]
Conclusion: IS6110 fingerprinting suggests that the rifampin-resistant isolates obtained from the Aegean region had a relatively high clustering rate and were clonally related. These findings showed that the rifampin-resistant isolates are actively transmitted between patients. Urgent measures should be taken to prevent the spread of these resistant strains