Effects of Beraprost Sodium Evaluated by Digital Infrared Thermal Imaging in Diabetic Patients with Peripheral Arterial Disease / 대한족부족관절학회지

PURPOSE: This study examined the effects of beraprost sodium on digital infrared thermal images in patients with peripheral arterial disease caused by type 2 diabetes mellitus. MATERIALS AND METHODS: Twenty-five diabetic patients with peripheral arterial disease were treated with beraprost sodium in a prospective, multicenter, cohort study from February 2013 to December 2014. Beraprost sodium (40 μg) was administered orally 3 times daily (120 μg/day) for 6 months. The visual analogue scale (VAS) and digital infrared thermal imaging (DITI) were performed to compare the blood flow improvement between before and after dosing. RESULTS: Among the 25 patients included in the evaluation, 22 patients completed the study. A significant increase in body temperature was observed in the front and left side, particularly in the plantar side in DITI compared to that before and after administration. An increase in body temperature was observed at the frontal part from 28.1℃±2.3℃ to 29.1℃±2.1℃ (p=0.021), at the left side from 27.8℃±2.4℃ to 28.6℃±1.9℃ (p=0.028), at the plantar part at 24.0℃±1.5℃, and at the plantar part at 27.1℃±2.4℃ (p < 0.01). The VAS decreased significantly from 5.4±1.3 to 2.7±2.0 after 6 months of treatment (p < 0.01). CONCLUSION: Beraprost sodium is a safe and easy-to use oral medication for diabetes peripheral arterial disease. It can be expected to increase the blood flow and decrease the lower extremity pain statistically after being taken for 6 months.

A Case of Multiple Eccrine Spiradenomas with Zosteriform Distribution / 대한피부과학회지

Eccrine spiradenoma is clinically characterized by a slowly growing, deep-seated nodule occurring most frequently on the ventral surface of the body. It is solitary in 95% of cases. Rarely, multiple lesions may be present and may occur in a linear or zosteriform pattern. Until now only two cases of eccrine spiradenoma in zosteriform pattern have been reported in Korean literatures. A 19-year-old male presented with multiple, gray, macular lesions in a zosteriform distribution along his left subscapular area. These 10-years-old lesions gave him occasional paroxysmal pain. Two years later, the lesions became palpable in the subcutis and were diagnosed as eccrine spiradenoma by an excision biopsy. During the 4 years thereafter, the remaining lesions grew slightly and became symptomatic, which resulted in a second surgical removal. We report a rare case of multiple eccrine spiradenomas with zosteriform distribution with observation of 6 years course.

A Case of Vulvar Syringoma with Pruritus / 대한피부과학회지

We report a case of vulvar syringoma in a 33-year-old woman who presented with a 1-year history of intermittent pruritus. Examination revealed multiple, bilateral, skin-colored to yellowish papules over the labia majora. Microscopically the lesions showed characteristic histological findings of syringoma. Vulvar syringoma is rare and usually asymptomatic. Herein, We present a rare case of syringoma which was limited to the vulva and sympromatic of intermittent pruritus.