Choroidal Neovascularization Characteristics and Its Size in Optical Coherence Tomography

The classification, size and activity of choroidal neovascularization (CNV) by optical coherence tomography (OCT) were compared with those obtained by fluorescein angiography (FA) and Indocyanine green angiography (ICG). This study included 32 patients (32 eyes) diagnosed as having CNV. The etiology of CNV was found to be age-related macular degeneration (AMD) or non-AMD. Patients were studied retrospectively by FA, ICG, and OCT. Of the 13 eyes with AMD, the boundary of the lesion could not be defined using FA in 7 patients. Among the 7 poorly defined CNV cases by FA, the identification of the boundary was possible in one case by OCT. The mean diameter of the classic well-defined lesions was 3500 +/- 421 micrometer by FA, 2624 +/- 1044 micrometer by ICG, and 1927 +/- 1272 micrometer by OCT. The size of the CNV by OCT was always smaller than by FA or ICG. Of the 19 eyes with Non-AMD, the boundary of the lesion could not be defined by FA in 5 patients. Among the 5 poorly defined cases by FA, the identification of the boundary was possible in 3 cases by OCT. The mean diameter of the well-defined CNV lesions was 2153 +/- 759 micrometer by FA, 1929 +/- 673 micrometer by ICG, and 1322 +/- 566 micrometer by OCT. Retinal thickness, which represents retinal edema, was found to be proportional to lesion size, although the relationship was not statistically significant. Regardless of CNV type, FA, ICG and OCT used in combination increase the specificity of diagnosis if their findings are compared.

Change of intraocular pressure, corneal flap and thickness by automated corneal shaper(R) in porcine eye

PURPOSE: To evaluate the performance of Automated Corneal Shaper(R)(ACS) METHODS: we analysed the changes in intraocular pressure, axial length and corneal thickness and its influence on corneal flap following keratectomy by ACS in 20 porcine eyes. RESULTS: Corneal flap was made by ACS with plate 160, and its size and thickness were measured. With the suction ring application, intraocular pressure rised from 17.0 +/-1.96 mmHg to 62.0 +/-11.8 mmHg (p=0.001), while corneal thickness and axial length were decreased from 1090 +/-75.1 micro meter to 1074 +/-73.7 micro meter(p=0.001) and from 19.94 +/-0.89 to 19.72 +/-0.73 mm (p=0.028) respectively. Thickness of corneal flap was 122 +/-23.9 micro meter and its diameter was 8.3 +/-0.15 mm in average. CONCLUSION: special attention is required during LASIK (laser in situ keratomileusis) with Automated Corneal Shaper(R) in order to prevent intraocular damage by abrupt rise in intraocular pressure and change of eyeball contour.

Vitreous Biopsy Using You's bottle: Safety and Effectiveness

PURPOSE: To evaluation of the safety and the usefulness of our "You's bottle" that we have invented for sampling vitreous. METHODS: We performed the vitreous sampling with our collection bottle in 13 patients who had undergone vitrectomy for diabetic retinopathy. We observed the usefulness and complications after sampling. Collected vitreous was used for analysis of protein components. RESULTS: There was no complication associated with collection bottle. The analysis of proteome was successful. CONCLUSIONS: Our study showed that "You's bottle" might be a useful tool for the research of vitreous.