Comparison of quality of life between hemophilic children receiving prophylaxis and on demand therapy in Tehran

Improving quality of life in a chronic disease such as hemophilia is a major goal of treatment. Hemophilic patients can be treated either prophylactically or on demand. Since haemophilia quality of life may be affected by the disease and treatment outcomes, comparison of these regimens in respect to quality of life outcomes provides useful information. The purpose of this study is to compare the quality of life between hemophilic children receiving prophylactic and on demand therapy in Tehran, Iran. A descriptive -comparative design was used. The sample of the study consisted of 60 hemophilic children which were recruited from haemophilia treatment centres in Tehran. Of these children 30 were receiving prophylactic therapy and 30 of them were treated on-demand .Data was collected by haemophilia-specific QoL questionnaire [HAEMO-QoL]. The questionnaire consists of 8 dimensions: physical health, feeling, view of yourself, family, friends, others, sport and dealing with haemophilia.The questionnaire consists of 18 items using a5-point scale.The Higher scores represent a poorer quality of life and lower scores represent better quality of life. Data were analyzed by SPSS 15 statistical software. The mean age of children was 5.3 +/- 1.2 and 6 +/- 1 in prophylactic and on demand therapy respectively. The mean total score of quality of life was 40 +/- 9.8 and 58 +/- 10.9 for children in prophylactic therapy and on-demand treatment respectively. There was a significant difference between the quality of life scores in two groups. Analysis of subscale scores showed a lower quality of life score for family domain in prophylactic therapy group, while the scores for family and physical health subscsles in on-demand group showed a poor quality of life. Results of the study suggest that quality-of-life may be better for haemophilia children treated prophylactically

relation between postpartum depression with total serum cholesterol changes before and after child birth

Postpartum depression is a severe and pervasive sadness with labile mood that affect 8-15% women after delivery. It can negatively impress mother-infant bonding. There are a lot of factors which make women vulnerable to postpartum depression so that controlling them can prevent from the postpartum depression incidence. Several researches have shown an association between serum cholesterol reduction and depression. The aim of present study is to determine relation between postpartum depression with total serum cholesterol changes before and after child birth in Lahijanian women in years 2006-2007. This research sought a descriptive-analytical design. Samples consisted of healthy Primigravidia women [101 persons] with normal labor, normal delivery at term, married, and a medium to high socio-educational level, without history of a depressive disorder, and metabolic disorders or hyperlipidemia. The excluded were the women with maternal or fetal complication before delivery, having problem with accepting infant gender, fetal death and being depressed during pregnancy. All women were visited in two stages: 3 weeks before the expected delivery and also 6 weeks after delivery. On both visits the Beck depression inventory and serum cholesterol registration questionnaire were completed. Data were collected using a questionnaire which had three sections: demographic characteristics, the Beck depression inventory and laboratory tests. Data were analysed using descriptive and inferential statistics [Spearman correlation coefficient and t-test] by SPSS computer software. Findings indicated that serum cholesterol declined considerably in the postpartum period, also it was shown that there was a significant correlation between reduced serum cholesterol and postpartum depression [r=-0.331, P<0.001]. Serum cholesterol reduction has a relation with postpartum depression

[Survey study of effective factors on maternal mortality in Kurdestan province from 1998 to 2002]

Introduction: pregnancy is a natural phenomena and basis of birth but can induce various dangers to mother and fetus. Since mother is the central part of family, maternal mortality would be an irreparable damage to the community. On average 10100 live births and 12 maternal mortalities occur in Kurdestan province each year the maternal mortality rate is therefore 118/100000 live births which in comparison to similar figure in whole country [37/100000 live births] is three times higher

Materials and Methods: this research is an analytic case-control study. Cases and controls were matched for place of residence and age at gestation. Cases [n=55] were chosen by census and controls [n=220] were chosen by random sampling. The tool used to collect data was questionnaire, validity and reliability of which was tested by content validity and test-retest method. The statistical testing used in this study were Chi square and odds ratio. Data were analyzed by SPSS .11 software

Results: most of maternal mortalities had occurred in women 18-35 years of age, illiterate and living in rural areas. Marivan had the highest maternal mortality compared to other surveyed cities [29.1%]. Prenatal care [OR= 22.7], parturition agent [OR= 9.85], use of one of the method of family planning [OR= 2.5] and parturition method [OR= 2.3] had meaningful relationship with maternal mortality

Conclusion: according to findings of this research, it is possible to decrease the maternal mortality by improving prenatal care and family planning and preventing parturition by uneducated midwives and avoiding unnecessary cesarian sections

[ role of intravenous albumin in the prevention of severe ovarian hyperstimulation syndrome in ART cycles]

The objective of this study was to evaluate the effect of ablumin on inhibition of severe ovarian hyperstimulation syndrome [OHSS] in women at high risk. A prospective, interventive and randomized study was planned and performed at the IVF department of the Royan Research Center. Ninety high risk patients from moderate to serere OHSS who were undergoing IVF ICSI cycles, were divided in two groups. 57 patients in the study group and 33 in the control group. At the time of oocyte recovery, 50gr human albumin in 500 ml of normal saline [N.S] was injected to the study group. The control group only received 500 ml N.S. All patients in study and control groups were matched for age, number of oocytes, level of Estradiol at the time of hCG injection, duration of Follicular phase, amount of hMG used and the number of the transferred embryos. Of the 57 patients in the study group, one had OHSS, while in the control group, 4 OHSS patient was found in 33 patients [1/8% versus 2%, p<0.05]. We conclude that prophylactic infusion of human serum albumin can reduce or mitigate severe OHSS in patients at high risk