Pigmented dentigerous cyst in a patient with multiple dentigerous cysts of jaws: a case report

In this paper, an unusual case of pigmented dentigerous cyst in a 37-year-old Iranian man with multiple dentigerous cysts of maxilla and mandible is reported. In addition to the characteristic histopathologic features of dentigerous cyst, numerous melanin granules which were distributed throughout the epithelial lining of one of these cysts were also noted. The histochemical study using Fontana's staining indicated that the pigment was melanin and many of the cells containing melanin were immunohistochemically positive for S-100 protein. Although no firm conclusion could be drawn from the present case regarding melanin origin in dentigerous cyst, the possible histogenesis of melanocytes in odontogenic lesions is discussed

Distribution of estrogen and progesterone receptors in Epulis Fissuratum

Epulides Fissurata [EF] are common proliferative and denture- induced lesions of the oral cavity with a predilection for female. This suggests a possible role for sex steroid hormones in the development and progression of these lesions. The objective of this study was the immunohistochemical evaluation of epulis fissuratum of the oral cavity for estrogen and progesterone receptors expression in epithelial, stromal, inflammatory and endothelial cells populations. In this cross-sectional study, 15 samples of formalin- fixed, paraffin- embedded epulis fissuratums including marginal mucosal tissues in 4 cases as a control group, were immuno-histochemically evaluated for estrogen and progesterone receptors protein expression. In 10 cases, estrogen receptor positivity was found within the epithelium and progesterone receptor immunoreactivity was present in 7 cases. Stromal cells exhibited estrogen and progesterone receptor immunostaining in many cases but only few cases showed expression of these receptors in the inflammatory and endothelial cells. Estrogen and progesterone receptors were also detected in some cases containing salivary glands tissue. Although chronic irritation may be the initiating factor for the occurence of epulis fissuratum, some of the cells in the lesion, could be potential targets for estrogen and progestrone hormones

[Comparison of Ag NORs count in exfoliative cytology of normal oral mucosa in smokers and non-smokers]

A strong causal relationship exists between cigarette smoking and development of oral squamous cell carcinoma, so oral screening using exfoliative cytology has been recommended to facilitate the early diagnosis of cellular alterations in oral mucosa and silver staining [AgNOR technique] has been proven to be of value in the detection of incipient cellular alterations. The purpose of this study was to compare the argyrophilic nucleolar regions [AgNORs] count of cells collected from normal mucosa of cigarette smokers with that obtained from non- smokers. In this cross-sectional study, cytologic smears of normal tongue, buccal mucosa and floor of the mouth from 19 smokers and 19 non- smokers were stained for AgNORs. The AgNORs count was established on 100 cells. The count value of groups were compared and analyzed using the Levens, Paired T, Student and Factorial tests. Using P<0.05 as the limit of significance. The AgNORs were round and had a clustered distribution in both groups. The mean AgNORs count was statistically higher in cells of smokers than non- smokers [P<0.05]. There was a significant difference between smears from the floor of the mouth and other anatomical sites in both groups. In this study, no correlation was found between AgNORs count and gender. Analysis of AgNORs suggests that there might be a correlation between the smoking habit and an increased rate of cellular proliferation in the oral mucosal cells

[Hydatid cyst of submandibular region report of a case]

Nowadays hydrated disease of internal viscera is by no means a rare finding in Medical practice in Iran. Although this disease has had a decline trend in comparison with decades ago, it is still a disease which comes into consideration in differential diagnosis of the liver, lung, adrenal, peritoneal masses, etc. affected patients usually present with signs and symptoms related to the involved organ and sometimes they are discovered on Laparotomy-Central nervous system is occasionally the host of this uninvited guest and exhibits symptoms of a space-occupying lesion. Head and neck excluding CNS is rarely involved by hydrated cyst. We report a case of hydrated cyst in the submandibular region which was discovered at operation