[Comparison of plasma glucose level among traumatic patients in casualty and emergency department]

There are several studies about the correlation of blood glucose level and prognosis in traumatic patients. To determine the relationship between the on-admission plasma glucose [G] level with the type and severity of trauma. In this analytical study, 270 patients who were admitted to the trauma center of Alzahra general hospital in 2006, evaluated for plasma G level, GCS, TS, and the type of trauma upon admission. In cases with plasma G [BS1] grater than 140 mg/dl on admission, the plasma G [BS2] was re-checked the next 24 hours. Data were analyzed using t-test and correlation ratio. Findings: The incidence of different types of trauma and their mean BS1 were as follows: head and neck trauma [45%, BS1=238 +/- 104 mg/dl], multiple trauma [28%, BS1=193 +/- 82 mg/dl], extremities trauma [16.1%, BS1=140 +/- 12 mg/dl], abdominal and chest trauma [7.4%, BS1=200 +/- 89 mg/dl], and pelvis trauma [2%, BS1= 152 +/- 10 mg/dl]. The Mean plasma G level in patients with TS=11-16, TS=6-10, and TS=1-5 was 130.74, 273.78, and 340 mg/dl, respectively. In the emergency stage of trauma, hyperglycemia is common. In addition, an increase in plasma G level has a direct correlation with severity of trauma and head injury

Production of 177Lu and formulation of Ethylene diamine tetramethylene phosphonate [EDTMP] kits as a bone-seeking radiopharmaceutical

Owing to its favourable decay characteristics 177Lu [T1/2= 6.71 d, Ebeta[max]= 497 keV] is an attractive radionuclide for various therapeutic applications. Ethylene diamine tatramethylene phosphonate [EDTMP] is one of the most widely used ligands which form stable complexes with various radionuclides and all the complexes. Enriched 176Lu2O3 was dissolved in 0.1 N HCl and evaporated several times and 176LuCl3 target was irradiated at 2.6x1013 n.Cm- 2.S-1 thermal neutron flux for 14 days.177LuCl3 was dissolved in 1N HCl. EDTMP was dissolved in double distilled water at pH=7.5-8.5 and freeze-dried kits was radiolabeled with 177LuCl3. Distribution studies were done in healthy mice. The yield of 177Lu was [220 TBq/g; 6000 Ci/g], the radionuclidic purity was 99%.The radiolabeling yield of EDTMP kits at 37°C after 30 min and 4 hours was 98 +/- 0.5% and after 72 hours was 90 +/- 2.1%, the in vitro stability in human serum at 37°C up to 72 hours post radiolabeling was 85 +/- 1.8%.The biodistribution studies of 177Lu-EDTMP and 177LuCl3 in normal mice showed skeleton uptake and low soft-tissue concentration. In this study, we produce 220 TBq/g [6000 Ci/g] of 177Lu by neutron activation of 176Lu in the Tehran Research Reactor. Our results showed 177Lu-EDTMP as a bone-seeking radiopharmaceutical. Due to its suitable nuclear characteristics 177Lu appears to be worthwhile for palliative therapy of bone metastasis