RESUMO
The physiological and biochemical parameters like body weight, packed cell volume, blood pH, blood glucose, total lipids, total proteins, albumin, globulin and akbumin/globulin ratio were determined in three groups of nine rabbits each before and after the induction of experimental conditions like dehydration, fever and diabetes. Statistically, significant differences were observed in these parameters when the normal animals were compared with their respective diseased group. These differences in the physiological and biochemical parameters in experimentally induced disease states acquaint of the necessity for analyzing these conditions for the changes in the absorption, distribution, protein binding and metabolic disturbances leading to alteration in the disposition kinetics of drugs
Assuntos
Animais de Laboratório , Hipertermia Induzida , Diabetes Mellitus Experimental , Testes Hematológicos , CoelhosRESUMO
The botanical and chemical background of the plants of genus acorus [family araceae] have been described. Many investigators have isolated and characterised a variety of compounds such as glucosides, amino acids, flavones, fatty acids and essential oils. Numerous applications of the plants as insecticides, plant growth inhibitors, antifeedants and hair growth sitmulant have been described. The pharmacological studies of the A. calamus rhizomes in drug preparation with varying content of beta-asarone have ben discussed in detail, since the A. calamus having a high content of beta-asarone has been proved to be carcinogenic