RESUMO
The aim of the present study was to evaluate clinically, radiographically and histologically the adjunctive treatment of periodontal intrabony defects by surgical debridment and local application of a single dose of simvastatin granules. Twenty intraosseous interproximal defects in 10 systemially healthy moderate to severe chronic periodontitis patients constituted the study sample. All patients received initial therapy, then when qualified for surgery defects were randomly divided into 2 groups. Group I defects were treated with surgical debridment and adjunctive use of local application of [2.2 mg] simvastatin granules. Group II defects were treated with surgical debridment alone. At baseline; 6 and 9 months post-surgery clinical and radiographic parameters evaluated included gingival index [GE], probing pocket depth [PPD], clinical attachment level [CAL], radiographic bone density [RBD] and linear radiographic measurement [LRM]. Both groups showed statistical reduction of PPD and gain in CAL after 9 months. Comparing both groups, there was a significant PPD reduction at 9 months and gain in CAL at 6 and 9 months [t= 2.333, 2.910] post operatively in gp I when compared to gp II. Gp I showed a statistical decrease in LRM and RBP at 6 and 9 months, whereas gp II revealed at decrease at 9 months ony. There was a significant decrease of LRM and RBP at nine months when gp I was compared to gp II [2.187, 1.579]. a histological study was carried out to assess the nature of healing 10 critical sized matched bilateral osseous defects were surgically induced at the interproximal area of mandibular 3rd and 4th premolars in 5 dogs, these defects were treated in as similar manner to their human counter parts, the animals were sacrificed at 4, 12 and 24 weeks post-surgery. Gp I revealed formation of a thick layer of new lamellated bone, typical functional orteination of periodontal ligament and enhancement of periodontal regeneration. In conclusion, simvastatin acted as a true osteoinductive material by promotion of new bone formation
RESUMO
The morphological pattern of invaginated occlusal fissures and the enamel thickness at the bases of these fissures, in a sample of 50 upper and 50 lower first permanent molars were investigated by optical microscope, using longitudinal bucco-lingual ground sections. This study showed that the deeply invaginated occlusal fissures were much more prevalent. The various forms of occlusal fissures of permanent first molars were found in the following percentages: V-type 13%, Y-type 17%, IK-type 30%, I-type 22%, U-type 13%, and irregular type 5%. Measurement of the depth of enamel between the bases of the fissures and dentin in 100 permanent first molars emphasize the potential risk of early post-eruptive carious extension to dentin. From the present study, it can be concluded that the occlusal fissures morphology of the first permanent molars play an important role in caries prevalence in Libyan children. Therefore, this study advocated the applications of fissure sealant on the occlusal surfaces of permanent first molars as soon as their eruption in the oral cavity