RESUMO
Hormonal modulation of in vitro biosynthesis of three prostatic secretory proteins, prostate specific acid phosphatase (PSAP), prostate specific antigen (PSA) and prostatic inhibin peptide (PIP) by human benign hyperplasia (BPH) tissue was studied. LH and inhibins caused increase in the synthesis of all three proteins whereas FSH enhanced the synthesis of PIP and PSA only but decreased PSAP synthesis. Prolactin and thyroid releasing hormone decreased synthesis of PIP and PSAP. However, PSA synthesis was enhanced by TRH and was decreased by prolactin. Estradiol caused significant increase in PSA and PSAP but no discernible changes in PIP synthesis were noticed. Testosterone caused an increase in PIP, PSA and PSAP. These data indicate that biosynthesis of PIP, PSA and PSAP by BPH tissue is under multihormonal regulation.
Assuntos
Fosfatase Ácida/biossíntese , Antígenos de Neoplasias/biossíntese , Estradiol/farmacologia , Hormônio Foliculoestimulante/farmacologia , Hormônios/farmacologia , Humanos , Inibinas/biossíntese , Hormônio Luteinizante/farmacologia , Masculino , Próstata/metabolismo , Antígeno Prostático Específico , Testosterona/farmacologia , Hormônio Liberador de Tireotropina/farmacologia , Biomarcadores Tumorais/biossínteseRESUMO
Effects of prostatic inhibin peptide and its synthetic fragments on FSH biosynthesis by the human pituitary and prostate, were examined in vitro. The results showed that FSH biosynthesis by prostatic tissue is modulated by these peptides in a similar fashion to that observed at the pituitary level.