RESUMO
Background and Objectives: Increased perinatal mortality incidence has been seen amongst patients whose precise gestational age is unknown. Trans cerebellar diameter is a newer parameter in the estimation of gestational age. Therefore, the present study was conducted with the aim to determine the accuracy of trans cerebellar diameter in predicting gestational age during second and third trimester of pregnancy. Materials and Methods: The present study was conducted in the Mithila Hospital,Janakpurdham for a period of 1 year. The study included a total of 160 females with singleton pregnancies during their 2nd or 3rd trimester. The characteristic butterfly appearance of the cerebellum hinted the location of posterior fossa. All the data was arranged in a tabulated form and analyzed statistically. Data was expressed in the form of mean with standard deviation. SPSS software16 was used for the analysis of the data. Results: The present study enrolled 160 subjects, out of which 80 were in their second trimester and 80 were in their third trimester. The mean transcerebellar diameter of subjects in second trimester was 20.22±4.87 and it was 36.01±2.89 amongst subjects in their third trimester. As the gestational age advances, the transcerebellar diameter also increases with it in a linear manner. Conclusion: Transcerebellar diameter can be used as a reliable parameter to estimate the gestational age and is also not altered in cases of intrautering growth restriction.
RESUMO
Aim: This trial is undertaken to evaluate the efficacy and safety of this FDC ointment for post-surgical patient management. This multi-centre, prospective, randomized, comparative, open-labeled, three-arm parallel group study involving 180 patients was conducted in patients with surgical wound. The trial was conducted at 2 centres and had 90 patients completed at each center. Methods: Patients were in randomized in three groups, to receive either the study formulation of Ornidazole 1% - Povidone iodine 5% FDC ointment (Group I ) or Povidone iodine 5% Ointment (Group II) or Ornidazole 1% Ointment (Group III). These ointments were applied for post surgical wound care. Dressing was done twice daily till the discharge of patients (Day 5-7). Patients were asked to use respective ointment for wound dressings after discharge. The patients were assessed for clinical wound improvement by using the Bates Jensen Wound Assessment Tool (BWATS). General and systemic examination was done at every visit of the patient. Results: Reduction in wound size was significant in all three groups from day 1 onwards. In group I exudates amount improved significantly from day 5 as compared to day 3, in Group II and Group III the improvement was from Day 8 onwards as compared to day 5. Peripheral tissue edema and Peripheral Tissue Induration improved in Group I and as compared to baseline. Epithelialization was statistically better in Group I and Group II from day 1 compared to baseline and in Group III it improved from day 5. No adverse event were seen in any of the groups. Conclusion: We concluded that the combination was better as compared to each individual drug in prevention of wound infection and promoting wound healing.