Hematological profile of patients of pancytopenia.

Background & objectives: To study the clinical presentation and etiological factors in various cases of pancytopenia and to study and correlate the hematological parameters including bone marrow aspiration and biopsy findings with clinical features. Material and Methods: The study was conducted in 100 patients admitted with clinical features of pancytopenia confirmed with hematological findings. Complete hemogram was done with peripheral smear examination and bone marrow aspiration and biopsy as and when required. Results : Total 100 patients who presented with pancytopenia were studied. Megaloblastic anaemia was the commonest cause constituting 28% of the cases followed by Iron deficiency anaemia(23%). Conclusion: Pancytopenia should be suspected on clinical grounds when a patient presents with unexplained anaemia, prolonged fever and a tendency to bleed.Megaloblastic anaemia is the commonest cause and other common causes are Iron deficiency anaemia and nutritional anaemia.

Giant myofibroblastoma of breast: a case report.

Myofibroblastoma of the breast is a very rare benign neoplasm usually seen in elderly male and is of very small size. A 40 year old nulliparous woman was admitted with chief complain of massive enlargement of left breast. The case was clinically diagnosed as Phyllodes tumor Left mastectomy was done. The tumor was histopathologically and immunohistochemically diagnosed as Myofibroblastoma. The case is reported because of its rarity and very rare clinical presentation.

Bilateral sex cord tumor with annular tubules of ovary without Peutz-Jeghers syndrome: a case report.

Ovarian sex cord tumor with annular tubules is a very rare tumor .Afourteen year old Nepali girl presented with abdominal distension and lower abdominal pain.On laparotomy bilateral ovarian masses were found. It was totally solid on the right side and was partially solid and partially cystic on the left side. The patient had no other symptoms and features of Peutz-Jeghers syndrome. Microscopic examination showed characteristic findings of sex cord tumor with annular tubules on both sides. The patient was doing well 2 months after surgery. The case is presented with review of literature because of the rare clinical presentation.

Malignant gastrointestinal stromal tumor of intestine: a case report.

Smooth muscle tumors of the alimentary tract are uncommon.Cancer of small intestine comprises less than 20% of all malignant tumors. A 65-year-old male patient was admitted with complain of pain in abdomen since 7 days. He was diagnosed as a case of acute intestinal obstruction and on laparotomy an extraluminal mass was found at jejunoileal junction. Histopathology revealed a malignant gastrointestinal stromal tumor (GIST) which was confirmed by immunohistochemistry. The case is reported with review of literature and criteria for differentiation between benign and malignant tumors are enumerated.