RESUMO
The study was aimed at evaluating the effects of sulphonyhireas on senlni HDL-cholesterol and its subJracdials ill type diabetes mellitus. Sixty three non-obese, newly diagnosed diabetic patients with a short history of disease were studied before and after treatment with sulphaiyhireas for a period of 6 months. We observed highly significant increases in total HDL and HDL-cholesterol after therapy. The HDL3 cholesterol did not change after therapy in the majority of patients and post-therapy rise of total HDL- cholesterol was almost entirely due to a rise in HDL2 cholestrol. Thus, we may conclude that HDL2 cholesterol is more important than HDL-cholesterol in the causation of atherosclerosis. The HDL2 cholesterol levels may predict the development of coronary atherosclerosis