RESUMO
The pharmacognostic and phytochemical investigations on the leaf, stem bark, and fruit of Zanthoxylum armatum were carried out. Macroscopic study of leaf, stem bark, and fruit of Z. armatum revealed some of the characteristic features like size, shape, color, odor and taste of the crude drug. Distinguishing fragments were identified from the powder drug. Leaf, bark, and fruit powder of this plant have higher values of total, acid insoluble, and water soluble ash as compared to the powder of this plant exhausted with ethanol and n- hexane. Extraction values in methanol were highest for leaves [20.10%] and fruit [11%], while bark showed highest value in chloroform [8.5%]. The extractive values varied among other parts with different solvents. Fluorescence analysis of the Z. Armatum leaf, stem bark, and fruit powder with various reagents showed characteristic coloration at day and under UV light. Quantitative phytochemical screening revealed the presence of many bioactive constituents in leaves, such as alkaloids [15.60+/-0.10 mg/g], sterols [71.60+/-0.10mg/g], saponins [21.57+/-0.12mg/g], tannins [34.43+/-0.21mg/g], phenols [11.66+/-0.33mg/g] and flavonoids [13.68+/-0.66mg/g]. Alkaloids [19.60+/-0.10mg/g], sterols [33.83+/-0.29mg/g], saponins [14.78+/-0.10mg/g], tannins [28.62+/-0.13mg/g], phenols [16.48+/-1.33mg/g] and flavonoids [18.33+/-1.22mg/g] were reported form the bark, while fruits were reported to have alkaloids [25.07+/-0.21mg/g], sterols [164.92+/-0.14mg/g], saponins [28.60+/-0.10mg/g], tannins [35.5+/-0.5mg/g], phenols [21.68+/-0.44mg/g] and flavonoids [22.8+/-1.33mg/g]. Z. armatum is an important medicinal plant, traditionally used for various ailments. This study will be helpful in the future pharmacognostic standardization of this important plant
RESUMO
To find out the frequency of compliance of patients using anti-depressants prescribed at out-patient department. Descriptive cross sectional study. This study was conducted in the out-patient department of Institute of Psychiatry, Benazir Bhutto Hospital, Rawalpindi from September 10,2010 till May 10,2011. One hundred and sixteen patients aged 18 years and above, presenting with moderate depressive illness, able to understand and speak Urdu, taking treatment for at least 4 weeks and belonging to both genders were recruited from out-patient department using consecutive [non-probability] sampling technique. Patients having severe depressive illness with psychotic features and severe agitation were excluded. Antidepressant Compliance Questionnaire was translated and validated through a pilot study and then the Urdu translation was orally administered to each participant for the assessment of compliance with antidepressant medication. Among the participants 74.1% were compliant and 25.9% were non-compliant with anti-depressant medications. This study found a high degree of patient compliance with anti-depressants. The results would help in early recognition of non-compliant patients, so that necessary changes could be made in the treatment plan to ensure better compliance