Dengue fever; clinico-pathologic correlations and their association with poor outcome

One of the major health hazards that has erupted in Pakistan within the recent past years and has caused loss of life of many young people is Dengue Fever. Main objective was to find clinico-pathologic parameters which are essentially associated with complications and contribute to the adverse outcome. This prospective study was conducted on 106 seropositive cases of dengue fever. Patients were taken from Abbasi Shaheed Hospital, Karachi from June 2008 to March 2009. The most common 3 hematological abnormalities were thrombocytopenia and leucopenia. Platelets count below 50 x 10 / microL was seen in [78%] cases and 49% 3 patients had total white cell count below 4 x10 /microL. Partial thromboplastin time was significantly prolonged in [26%] cases whereas prothrombin time was normal in all patients. Liver enzymes both Aspartate Aminotransferase [AST] and Alanine Amino-transferase were significantly elevated in [60%] patients. Blood urea nitrogen [BUN] and creatinine was deranged in [23%] patients. Fever was the most common clinical presentation [86% of the patients]. Hematological parameters [low platelet count, low total leucocytes count, prolonged APTT and raised hematocrit] and biochemical parameters [raised aminotransferases, blood urea nitrogen] have strong association with the complications of dengue fever and hence are associated with the poor outcome of disease

Anaemia in second trimester of pregnancy

The prevalence of anaemia during second trimester of pregnancy was studied among 1830 women, who utilized the antenatal services of Shaikh Zayed Hospital, Lahore. The duration of pregnancy among these women was between 13 and 24 months. The mean age was 25.9'4.6 years and mean gravidity was 2.6 WHO's definition of anaemia of second trimester [Hb < 10.5 g/dl] was used as a cut-off point. According to this definition, 14.5% women were anaemic. The results have been compared with other studies