RESUMO
Background: Nausea vomiting of pregnancy [NVP] is a common problem .A severe form called hyperemesis gravidarum occurs in 0.3-2.3% of pregnancies, which can adversely affect the lifestyle. This study is conducted to improve the confidence of obstetricians for treatment of nausea and vomiting of pregnancy
Objective: To determine the efficacy of doxylamine succinate with pyridoxine combination in nausea and vomiting of early pregnancy
Methods: Study conducted at Dr. Ziauddin University and Hospitals Karachi, from 25-02-2011 to 25-07-2011. Study design was case series, during the period of study total number of OPD patients in gynaecology and obstetrics department Ziauddin hospital were 821, out of them 190 patients of 20 years to 39 years of age with 9+ 2 weeks gestation were enrolled and sample was taken by Consecutive sampling
Results: 182 [95.8%] patients reported improvement in symptoms i.e. positive efficacy, 7 patients [3.7%] reported no difference in nausea vomiting and only 1 patient i.e. 0.5% reported aggravation of her symptoms. Total PAQUE score before treatment was as high as 12.3526 with standard deviation of 2.12739, which reduced to 5.7211 with standard deviation 2.0908 after treatment of nausea vomiting with doxylamin succinate + pyridoxine combination. P value calculated for total PAQUE score before and after treatment is 0.000
Conclusion: This study concluded that for nausea and vomiting of pregnancy, doxylamine succinate is effective when given for moderate to severe symptoms. So it should be considered as 1st line of treatment for nausea and vomiting of pregnancy
RESUMO
Objective: To review the deliveries of macrocosmic babies and their obstetrical and neonatal outcomes
Methods: A prospective case control study involving a total of 3700 deliveries at term of macrocosmic babies between Jan 2011 to Dec 2012 in Ziauddin Hospital Kemari Campus. The study concerned risk factors, mode of delivery and the incidence of maternal and perinatal complications
Results: Macrosomia occurred in 5.2% of all deliveries. The main risk factors of macrosomia identified in our study were multiparty and diabetes mellitus. The significant maternal complications were caesarean section, postpartum hemorrhage and perineal tear. Significantly male gender, shoulder dystocia and admission to NICU were noted in macrosomic group compared to controls
Conclusions: Macrosomia is potentially dangerous for the mother and the neonate. It is important to identify the suspected fetal macrosomia to prevent its risk factors and complications. There is a need to provide all delivery facilities and care services to prevent and reduce the maternal and neonatal complications