Cytological grading of breast cancer according to robinson's grading system

Objective: To see the correlation between cytological parameters and grading of breast cancer according to Robinson's grading system on Fine needle aspiration smears. Study design: It was a correlational descriptive study

Study Design: It was a corelational descriptive study

Place and Duration of Study: It was conducted in the Histopathology Department, Army Medical College, National University of Sciences and Technology[MUST], Rawalpindi, Pakistan from Nov 2012 to Nov 2013

Material and Methods: All cases diagnosed as breast cancer [C 5] or suspicious of breast cancer [C 4], on Fine needle aspiration cytology, were included in the study and women already taking treatment were excluded. A total of 102 samples were included in the study through non probability convenience sampling

Result: The cytological parameters of Robinson's grading system including cell dissociation, nuclear margins and nuclear chromatin showed weak correlation with tumor grade. While cell size, cell uniformity and nucleoli showed moderate correlation. All the parameters were statistically significant with p-value<0.05

Conclusion: This study concludes that all the cytological parameters of Robinson's grading system have correlation with tumor grade

Histopathological study of benign Melanocytic naevi

To study the histological spectrum and types of benign melanocytic naevi and to observe unusual/atypical histological features in these lesions. An observational study with prospective data. 1st June 1997 to 30th June 1998 at department of Pathology PNS Shifa, Karachi. A total of 50 consecutive cases of melanocytic naevi were studied. Skin biopsies were taken by the Dermatologist from the patients with a primary clinical diagnosis of naevus/mole. Relevant data was recorded. Majority of cases 24[48%] were in the third decade with female preponderance [56%]. Commonest site was the face [66%]. Thirty percent cases showed lentiginous proliferation. Acanthosis was observed in 26% cases and effacement in 12%. Twelve percent cases showed mild patchy infiltration by the inflammatory cells. Foreign body reaction along with inflammation was seen in 8% cases. Nuclear pleomorphism with slight variation in size, shape and staining was observed in 8% of the lesions. No architectural disarray or other atypical histological features fulfilling the criteria of dysplastic naevus or malignancy were observed. Face was the most common site and intradermal naevus was the commonest lesion. Few histological features like lentiginous proliferation, multinucleated naevus cells, foreign body reaction, fatty infiltration, linear fibrosis and acanthosis were observed. However no cytological features for dysplasia or malignancy were present