Micro hardness of dental tissues influenced by administration of aspirin during pregnancy / Microdureza de los tejidos dentales influenciada por la administración de aspirina durante el embarazo

The study is associated with the effect of aspirin (Acetyl Salicylic Acid) on the microhardness of mineralized tissues of the offspring's teeth, in response to the ingestion of the drug during pregnancy. Aspirin is a widely used analgesic and antipyretic medicine, for symptomatic treatment. Misuse of this drug during pregnancy may instigate developmental defects in offspring. An experimental control study was designed, in which female rabbits were taken as representative mammalian models and treated with aspirin during pregnancy. Their offspring's teeth were used to assess the microhardness of dental tissues. The rabbits were alienated into two groups, treated and control, consisting of seven rabbits in each set (n= 7). Microhardness was evaluated in three types of the sample teeth. The total number of teeth examined were, 2x7x12= 168 samples. Vicker's Hardness degree values were measured and recorded vis-à-vis (50 g for 15 s with 3 indentations per specimen on enamel and dentine separately). The range of hardness obtained was statistically analyzed and the Student's t-tests was applied, with the aid of SPSS version 20. The P-values for both enamel and dentine from maxillary incisors and molars were less than 0.05. The same trend was observed in the mandibular teeth. However, a teratogenicity of Acetyl Salicylic Acid was pragmatic in the recent in vivo studies. Based on the analysis, it was evident that the aspirin administration could produce negative effects leading to reduction in the microhardness of dental tissues of the offsprings.

El estudio asocia el efecto de la aspirina (ácido acetil salicílico) sobre la microdureza de los tejidos mineralizados de los dientes de crías, en respuesta a la ingesta del fármaco durante la preñez. La aspirina es un analgésico y antipirético ampliamente utilizado para el tratamiento sintomático. El mal uso de esta droga durante la preñez puede inducir defectos en el desarrollo de las crías. Se diseñó un estudio experimental de control, en el que se tomaron conejas como modelos de mamíferos representativos y fueron tratados con aspirina durante la preñez. Los dientes de sus crías fueron utilizados para evaluar la microdureza de los tejidos dentales. Los animales fueron distribuidos en dos grupos, tratados y control, con siete animales en cada grupo (n= 7). La microdureza se evaluó en tres tipos de dientes de la muestra. El número total de dientes examinados fueron 168 (2x7x12). Se midieron y registraron valores del grado de dureza Vickers vis-à-vis (50 g por 15 s con 3 indentaciones por especimen sobre el esmalte y la dentina por separado). Se analizó estadísticamente la gama de dureza obtenida y se aplicaron pruebas t de Student con la ayuda del programa SPSS versión 20. Los valores de p para el esmalte y la dentina de los incisivos maxilares y molares fueron menores a 0,05. Se observó la misma tendencia en los dientes mandibulares. Sin embargo, teratogenicidad producto del ácido acetil salicílico se encontró en recientes estudios in vivo. De acuerdo al análisis de los resultados, se evidenció que la administración de aspirina provocó efectos negativos que determinaron la reducción de la microdureza de los tejidos dentales de las crías.

effect of curing cycle of denture base [PMMA] on microcolonization of candida albicans

The purpose of the study was to assess the growth of Candida Albicans on Polymethylmethacrylate [PMMA] as a denture base, using various curing cycles. Total 200 samples of denture bases were prepared divided into five categories, cut into 2x2 cm, with the thickness of 1.0 mm for the analysis. 160 out of them were further divided into 4 groups for heat cure water bath polymerization. They were assessed on different temperatures i.e. 45[degree sign] c, 100 [degree sign] c 70[degree sign] c, and 70 [degree sign] c for the time span of 45, 60, 420 and 540 min respectively. The specimens of the 5th group were cured chemically. Every specimen of all the five groups was kept in the bottles along with the food stuff for 12, 24, 168, and 336 hrs. The specimens were then mounted on the glass slides to examine under the light microscope for the analysis of Candida Albicans. Results showed that the growth of Candida Albicans observed to be reduced in heat cure polymerization as compared to the ones, cured chemically. Thus concluded that among all the sample types, the group D cured at the temperature of 70 [degree sign] c for 540 min have shown the minimum growth of Candida Albicans

Gender specific prevalence of gingival disease among the patients visiting baqai dental hospital

The aim of the study was to investigate the prevalence of gingival disease with regards to the age and sex of the patients who sought treatment from Baqai Dental Hospital. Out of 746 patients, 524 [71.18% male and 28.82% female] were diagnosed as suffering from gingivitis, both acute and chronic. Standard protocol procedures for examination and diagnosis of gingival disease were followed. Lack of proper oral hygiene was concluded as the dominant causative factor

Effect of lithium on the developing teeth of rabbits

The objective of the present study was to evaluate the changes in the dimensions of the teeth in new born babies of the mothers who receive lithium for a long time during pregnancy. The incidence of congenital defects due to Lithium was studied because, oral and dental structures are frequently the sites of adverse drug reactions. These include salivary glands, oral mucosa, periodontal tissues, teeth, alveolar bone, and other structures. The study was conducted on the female rabbits, which were kept on this specific drug during pregnancy. The off springs of these treated female rabbits were used for research purpose. They were sacrificed and the teeth were examined for the congenital defects developed during intrauterine life. This study was expected to provide suggestions for the use of this drug during pregnancy. The results showed large variations by analysing statistically in the different teeth i.e. the size reduced in maxillary incisors, first and second molars only. The nature of the insult is unlikely to be determinable and the results are generally not in accordance with the predicted outcome. However, the drugs should be used by doctor's prescription only, especially during pregnancy, avoiding the teratogenic effect on the dentition of the new borns