RESUMO
Objective: The present study was designed to assess the role of vitamin-D, in the development of autoimmune thyroid dysfunction in newly diagnosed schizophrenics
Methods: For the present study 100 patients and 100 controls were screened out and studied for their thyroid antibodies, GSH, homocysteine, NOS and vitamin D levels by appropriate protocols to assess the underlying mechanism involved in the schizophrenics susceptible to autoimmune thyroid diseases
Results: The results of the present study depicted that in schizophrenics, levels of cytokines like IL-6 [7.98 +/- 0.67 pg/ml], TNF-alpha, [40.76 +/- 6.98 pg/ml], homocysteine [16.98 +/- 1.09 micro mol/L], Tg-Ab [30.93 +/- 3.87 IU/L], TPO-Ab [10.33 +/- 1.78 IU/L] and TSHr-Ab [3.76 +/- 0.055 IU/L] increased whereas, those of Vit-D [12.76 +/- 0.99 pmol/L], NOS [5.99 +/- 0.87 IU/L], GSH [4.48 +/- .965 micro g/dl] and NO [16.87 +/- 3.98 ng/ml] were decreased in the patients as compared to healthy control subjects
Conclusion: Vitamin-D in schizophrenia is involved in augmentation of hyperhomocysteinemia, inflammation, oxidative stress and thyroid antibodies, thereby playing a significant role not only in induction of schizophrenic symptoms but may also result in autoimmune thyroid diseases. Thus, earlier detection and rectification of its levels are helpful to limit the miseries of schizophrenia
RESUMO
Current study was conducted to determine the fluctuations of various circulating biomarkers including thyroid hormones, hepatic enzymes, oxidative stress markers as well as electrolytes in schizophrenics. Cross Sectional Study. This study was conducted at Psychiatric Clinic of Jinnah Hospital, Mental Hospital from Jan. 2013 to Oct. 2013. Seventy five acute schizophrenics and twenty five healthy individuals were selected for this study. Patients with chronic infections, diabetic history, liver disease or any other history of drugs including smoking and/or drinking alcohol were excluded from the study. Elevated levels of oxidative stress in the form of malondialdehyde [MDA] [7.8 +/- 2.71*] were observed in schizophrenics. Similarly raised levels of T3 [6.9 +/- 1.31*] and T4 [61.2 +/- 15.44*] were found in patients as compared to control. Electrolytes like Na, K, Ca and Mg showed alterations in the serum of both patients and control. All the circulating biochemical markers were statistically significant [P<0.05]. It is concluded that lipid peroxidation may has association with thyroid hormones and electrolytes. Moreover, alleviated concentration of anti-oxidant biomarkers like SOD, catalase and GSH may play a central role in schizophrenics and anti-oxidant therapy may be useful for the management of this psychiatric disorder