RESUMO
The Institute for Medical Research, Malaysia, was designated the National Reference Laboratory for Poliomyelitis Eradication (NRLPE) in 1992. Since then, our Polio Laboratory has collaborated actively with the Disease Control Division, Ministry of Health (MOH), Malaysia and WHO towards achieving polio eradication. Since 1992, the NRLPE has investigated 1,063 stool specimens from 641 acute flaccidparalysis (AFP) cases. One hundred and one enteroviruses were isolated from these specimens. Positive cell cultures were confirmed by microneutralization assay using standard WHO antisera. All enterovirus isolates were sent to the Victorian Infectious Disease Reference Laboratory in Melbourne, Australia, for further identification and poliovirus intratypic differentiation. Thirty-one out of these 101 virus isolates (30%) were polioviruses (PV) and the remaining 70 (70%) were non-polio enteroviruses (NPEV) which included coxsackie B viruses, echoviruses and enterovirus 71. Three of the poliovirus isolates were wild-type polioviruses isolated in 1992 which were the last wild-type polioviruses isolated in Malaysia. The rest were vaccine-related Sabin-like strains. Monthly reports of the virological investigation of AFP cases are sent to WHO and to the MOH, AFP control committee. The NRLPE continues to play an integral role in AFP surveillance and is committed to the WHO's goal of global polio eradication by the year 2005.
Assuntos
Doença Aguda , Controle de Doenças Transmissíveis , Enterovirus/isolamento & purificação , Humanos , Programas de Imunização , Incidência , Malásia/epidemiologia , Paraplegia/epidemiologia , Poliomielite/epidemiologia , Poliovirus/isolamento & purificação , Vacina Antipólio Oral/administração & dosagem , Vigilância da População , Avaliação de Programas e Projetos de Saúde , Organização Mundial da SaúdeRESUMO
A total of 100 cases with chronic diarrhoea having no apparent cause were investigated. Fifty seven of these cases fulfilled the diagnostic criteria of ulcerative colitis. Fortyone of these 57 patients were treated for acute amoebic dysentery during the initial episodes of their illness. Since attack of acute amoebic dysentery is liable to produce post-dysenteric ulcerative colitis, it is possible that ulcerative colitis exist in this country in at least 2 forms, idiopathic and post-dysenteric.