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Objective To investigate the expression of insulin-like growth factor Ⅱ mRNA-binding protein 3( IMP3 ) in transitional cell carcinoma of bladder( TCCB ) and its clinical significance. Methods The IMP3 expressions in 6 normal bladder tissues and 48 TCCB tissues were determined by immunohistochemistry staining, and the relationships between IMP3 expression and gender, age, pathological grading and staging were analyzed statistically. Results The positive expression rate of IMP3 was 62.5% ( 30/48 ) in bladder cancer,which were significantly higher than that in normal control ( 0/6 ) ( P ＜ 0. 05 ). The positive rate of IMP3 expression were significantly lower in superficial TCCB ( 46. 15%, 12/22 ) or early TCCB [ Grade Ⅰ 12. 5%(1/8) ,Grade Ⅱ 60. 0% (12/20) ] than that in invasive TCCB [T2 or above,81.8% (18/22) ] or advanced TCCB [ Grade Ⅲ ,85% ( 17/20 ) ] ( Ps ＜ 0. 05 ). Conclusion IMP3 is a promising biomarker for eraly detection and assessment of the malignancy degree in TCCB.
RESUMO
<p><b>OBJECTIVE</b>To investigate the effect of transperineal puncture drug injection in the treatment of chronic prostatitis.</p><p><b>METHODS</b>Forty cases of chronic prostatitis underwent transperineal puncture drug injection. Bacterial culture and antimicrobial agent sensitivity tests were conducted on the prostatic fluid of the patients. A sensitive antimicrobial agent was selected, mixed with lidocaine and dexamethasone, and injected transperineally into the prostate at intervals of 7 days and 4 times as one course. After one month, the effect was evaluated and the patients were followed up for 6 months.</p><p><b>RESULTS</b>Among the 40 cases, the cure rate was 52.5% (21/ 40), the alleviation rate 40% (16/40), the nullify rate 7.5% (3/40) and the total effectivity rate 92.5%. No relapse was found in the 28 followed-up cases.</p><p><b>CONCLUSION</b>Transperineal puncture drug injection is a safe and effective way in the treatment of chronic prostatitis.</p>