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Objective To investigate the clinical therapeutic effect of abdominal acupuncture on rheumatoid arthritis.Methods Sixty patients with rheumatoid arthritis were randomly allocated to treatment and control groups, 30 cases. The treatment group received abdominal acupuncture and the control group, conventional acupuncture. Pre-/post-treatment changes in erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) and C-reactive protein (CRP) were observed after three courses of treatment. The clinical therapeutic effects were compared between the two groups.Results There were statistically significant pre-/post-treatment differences in ESR, RF and CRP in the two groups (P<0.01). There were statistically significant post-treatment differences in ESR, RF and CRP between the treatment and control groups (P<0.01). The total efficacy rate was 86.7% in the treatment group and 56.7% in the control group; there was a statistically significant difference between the two groups (P<0.05).Conclusion Abdominal acupuncture is an effective way to treat rheumatoid arthritis.
RESUMO
Objective To investigate the efficacy of transverse insertion of thick needles into the Du meridian in treating rat ischemic facial paralysis and preliminarily explore the possible mechanism by which it produces a therapeutic effect. Methods Sixty Wistar rats were randomly allocated to groups A (transverse insertion of thick needles), B (basic Western drugs), C (blank control) and D (sham operation), 15 rats each. A rat model of ischemic facial paralysis was made using a modified vascular occlusion method in all the rats. Facial nerve deficits were scored in every group of rats during treatment. At 1 day after model making, group A was treated by transverse insertion into point Shendao and 4-hour retention of needle, once daily, for a total of 14 days; group B was treated by an oral gavage of prednisone and intraperitoneal injection of vitamine B12, once daily, for a total of 14 days. Groups C and D were not treated. In 4 rats randomly chosen at 3, 7 or 14 days after model making, facial nerve concomitant intrinsic vascular tissue HIF-1αprotein was measured by an immunohistochemical method; serum NO, by enzyme-linked immunosorbent assay; serum ET content, by radioimmunoassay.Results After 7 days of treatment, the neurological deficit score increased gradually in groups A and B and there was a statistically significant difference compared with after model making in the two groups (P<0.01). After 7 days of treatment, there was a statistically significant difference in the neurological deficit score in groups A and B compared with groups C and D (P<0.05) and between groups C and D (P<0.05). After 14 days of treatment, there was a statistically significant difference in the neurological deficit score between group A or B and group C (P<0.05) and between group B or C and group D (P<0.05). In group A, there was a statistically significant difference in the neurological deficit score after 14 days of treatment compared with after 7 days of treatment (P<0.05). After 3, 7 and 14 days of treatment, there was a statistically significant difference in HIF-1αMOD value in groups A , B and C compared with group D (P<0.01). After 3 and 7 days of treatment, there was a statistically significant difference in HIF-1αMOD value between group A or B and group C (P<0.05). In groups A and B, there was a statistically significant difference in HIF-1αMOD value after 3 and 14 days of treatment compared with after 7 days of treatment (P<0.05). After 3 and 7 days of treatment, there was a statistically significant difference in serum NO content between group A or B and group D (P<0.01). In groups A and B, there was a statistically significant difference in serum NO content after 7 days of treatment compared with after 3 days of treatment (P<0.05). After 3 and 7 days of treatment, there was a statistically significant difference in serum ET content in groups A , B and C compared with group D (P<0.05). In groups A and B, there was a statistically significant difference in serum ET content after 7 days of treatment compared with after 3 days of treatment (P<0.05).Conclusions Transverse insertion of thick needles into the Du meridian can effectively promote rat’s recovery from ischemic facial paralysis. The mechanism by which it produces a therapeutic effect may be regulating the expression of tissue HIF-1α and the NO and ET contents of serum.