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Objective Objective to investigate the changes of D-dimer and hypersensitivity C reactive pro-tein(CRP)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECPOD)and their effects on prognosis.Methods From January 2014 to January 2016,104 cases of AECOPD patients were en-rolled in the study.According to the prognosis,they were divided into death group and survival group.D-di-mer and CRP were detected and the concentration changes were observed.Results There was no significant difference in CRP and D-dimer between the two groups on day 1 after admission(P> 0.05).While On the third day,the fifth day and the end of discharge,the concentrations of CRP and D-dimer in the death group were significantly higher than those in the survival group(P<0.05).Conclusion The continuous elevation of D-dimer and CRP suggests that the prognosis of AECOPD patients is poor,so the concentrations of D-dimer and CRP can reflect the severity of the patient′s condition and is helpful in the prognostic estimation.
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Objective To study the relationship between serum interleukin‐17(IL‐17) ,acidophil cationic protein(ECP) ,immuno‐globulin E(IgE) and the severity of asthma .Methods A total of 84 patients with asthma were enrolled as asthma group ,who were divided into remission group and acute episode group .In addition to that 84 healthy persons were recruited as control group .The concentrations of serum IL‐17 ,ECP and IgE in different groups were compared .Results The concentrations of serum IL‐17 ,ECP and IgE in asthma group were statistically significantly higher than those in control group(P< 0 .05) .Among the patients with bronchial asthma ,serum levels of ECP and IgE in acute episode group were statistically significantly higher than those in remission group(P<0 .05) .There was positive correlation between serum ECP level and serum IgE level in asthma group(r=0 .432 ,P<0 .05) ,there was no significant correlation between serum IL‐17 level and serum levels of ECP and IgE ,but in acute episode group , serum IL‐17 level positively correlated with serum levels of ECP and IgE(r= 0 .327 ,0 .349 ,P< 0 .05) .Conclusion IL‐17 is in‐volved in mediating eosinophilic inflammation of asthma ,ECP and IgE levels have important clinical significances for predicting and treating asthma patients .