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Chinese Journal of Biotechnology ; (12): 719-724, 2005.
Artigo em Chinês | WPRIM | ID: wpr-237084

RESUMO

The hIL24 cDNA sequence was cloned into prokaryotic high expressive vector pET-21a(+) and recombinant hIL24 was expressed in E. coli with IPTG induction. The purified recombinant hIL24 exhibits following functions in HeLa cell: inhibiting cell growth, inducing apoptosis, inducing PMBC to secrete IL-6, TNF-alpha, IFN-r and inhibiting blood vessel formation. Our preliminary results suggest that the apoptosis induced by rhIL24 is through down-regulating expression of anti-apoptosis factor Bcl-2 and activation of mitochondria apoptosis pathway.


Assuntos
Feminino , Humanos , Apoptose , Escherichia coli , Genética , Metabolismo , Células HeLa , Interleucinas , Genética , Alergia e Imunologia , Mitocôndrias , Metabolismo , Proteínas Proto-Oncogênicas c-bcl-2 , Metabolismo , Proteínas Recombinantes , Genética , Alergia e Imunologia
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