Expression significance of serum miR-27, miR-93, BMP-15 in patients with polycystic ovary syndrome / 中华内分泌外科杂志

Objective:To explore the expression significance of serum MicroRNA-27 (miR-27), MicroRNA-93 (miR-93) and bone morphogenetic protein 15 (BMP-15) in patients with polycystic ovary syndrome (PCOS) .Methods:63 PCOS patients admitted to Yantai Yantaishan Hospital from Aug. 2015 to Jan. 2019 were selected and divided into the obese group (obese PCOS, BMI≥25 kg/m 2, n=22) and the non-obese group (non-obese PCOS, BMI<25 kg/m 2, n=41) according to body mass index (BMI). 30 healthy women with normal physical examination during the same period were selected as the healthy group. Serum miR-27, miR-93 expression levels and bone morphogenetic protein 15 (BMP-15) concentration of the three groups were analyzed, and endocrine metabolism indicators of the three groups were compared. Receiver operating characteristic curve (ROS) was used to evaluate the predictive value of serum miR-27, miR-93 and BMP-15 for PCOS and obese PCOS patients. Results:(1) Endocrine indicators: Compared with the healthy group, FSH was lower in the obese group and the non-obese group, and T, LH/FSH and IR were higher ( P<0.05) ; Compared with the non-obese group, T and IR were higher in the obese group ( P<0.05) ; (2) Serum miR-27, miR-93 and BMP-15: Compared with the healthy group, serum BMP-15 concentration was lower in the obese group and the non-obese group, and serum miR-27, miR-93 expression levels were higher ( P<0.05) ; Compared with the non-obese group, the serum miR-27 and miR-93 expression levels in the obese group were higher ( P<0.05) ; (3) miR-27, miR-93 and BMP-15 had predictive value for PCOS, and the area under the curve of BMP-15 was the highest ( P<0.05) ; (4) miR-27 and miR-93 had predictive value for obese PCOS, and the area under the curve of miR-93 was the highest ( P <0.05) . Conclusions:In addition to significant endocrine index disorders in obese PCOS patients, serum miR-27 and miR-93 are highly expressed and the level of BMP-15 is relatively low. BMP-15 can be used as an effective parameter to assist in the diagnosis of PCOS, and miR-93 can be used as an effective parameter to assist in the diagnosis of obese PCOS.

Study on clinical extinction and cortex lesion / 中国组织工程研究

ObjectiveTo study the effect and clinical meaning and pathogenic of extinction on cerebral cortex lesion. MethodsTactile extinction to classical extinction test(simple stimuli)and modified Quality extinction test(QET)were used. ResultsThe positive rate of ex-tinction using modified QET was higher than that of simple stimuli; left cortex lesion could result in extinction both in the contralateral side andthe ipsilateral side;left frontal sites lesion caused ipsilateral extinction. Conclusion: The modified QET was more sensitive than simplestimuli; modified QET showed extinction has competiting and restricting effect at 2 different levels, the mechanism of extinction is correlatedto competition and adventage restraint of diplo-hand cerebral hemisphere and liaise correliation fiber of diplo-hand cerebral hemisphere; thehighesttthe positive rate of extinction was observed in left parietal lesions.